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Table 1 Top five prognosis-related canonical pathways in SHH subgroup

From: Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma

Database Name of gene set (GSEA) Exploratory dataset (n = 85) Validation dataset (n = 36) 1000 bootstrap datasets (n = 121) Representative core genes**
HR* p-value HR* p-value % of p-value < 0.05
PID p53 pathway 4.59 < 0.0001 3.19 0.127 100.0 TRIM28,CCNA2,ABL1,SETD7,CSE1L,HIPK2,RPL11
  PLK1 signaling events 2.02 0.0035 1.72 0.093 95.6 NUDC,PLK1,AURKA,TPX2,BUB1,CDC20,TPT1, BORA,CENPE,KIF20A,PRC1,CCNB1,CDC25C,WEE1,ECT2
  Aurora B signaling 1.73 0.0155 1.84 0.086 91.9 CDCA8,SMC2,AURKA,KIF2C,BUB1,RACGAP1, BIRC5,NCAPD2,KIF23,KIF20A,NCAPH
  FOXM1 transcription factor network 1.89 0.0119 1.75 0.109 90.8 PLK1,CCNA2,FOXM1,BIRC5,NEK2,ETV5, CCNB1,CENPF,BRCA2,CDK4,CHEK2,CKS1B
KEGG Alanine aspartate and glutamate metabolism 4.85 0.0001 1.76 0.432 94.3 PPAT,GLUD1,GPT2
  RNA polymerase 1.96 0.0032 2.36 0.022 93.3 POLR2E,POLR3H,POLR2B,POLR2J,POLR2D, POLR3K,POLR1B,POLR1A
  Basal transcription factors 2.48 0.0002 1.49 0.580 91.6 GTF2F1,TAF4,GTF2A1L,TAF11
BIOCARTA Cyclins and Cell Cycle Regulation 1.92 0.0127 3.17 0.029 91.7 CCNA1,CDKN2C,CCNB1,CDC25A,TFDP1,CDK4
  Proteasome Complex 1.71 0.0053 1.57 0.274 79.1 PSMB7,PSMA7,PSMD14,PSMB2
  1. * Hazard ratio per 0.1 increment in average relative expression of core genes
  2. ** Representative core genes are significantly associated with overall survival (p-value < 0.05) in Cox regression analysis with all samples