From: Subgroup-specific prognostic signaling and metabolic pathways in pediatric medulloblastoma
Database | Name of gene set (GSEA) | Exploratory dataset (n = 85) | Validation dataset (n = 36) | 1000 bootstrap datasets (n = 121) | Representative core genes** | ||
---|---|---|---|---|---|---|---|
HR* | p-value | HR* | p-value | % of p-value < 0.05 | |||
PID | p53 pathway | 4.59 | < 0.0001 | 3.19 | 0.127 | 100.0 | TRIM28,CCNA2,ABL1,SETD7,CSE1L,HIPK2,RPL11 |
 | PLK1 signaling events | 2.02 | 0.0035 | 1.72 | 0.093 | 95.6 | NUDC,PLK1,AURKA,TPX2,BUB1,CDC20,TPT1, BORA,CENPE,KIF20A,PRC1,CCNB1,CDC25C,WEE1,ECT2 |
 | Aurora B signaling | 1.73 | 0.0155 | 1.84 | 0.086 | 91.9 | CDCA8,SMC2,AURKA,KIF2C,BUB1,RACGAP1, BIRC5,NCAPD2,KIF23,KIF20A,NCAPH |
 | FOXM1 transcription factor network | 1.89 | 0.0119 | 1.75 | 0.109 | 90.8 | PLK1,CCNA2,FOXM1,BIRC5,NEK2,ETV5, CCNB1,CENPF,BRCA2,CDK4,CHEK2,CKS1B |
KEGG | Alanine aspartate and glutamate metabolism | 4.85 | 0.0001 | 1.76 | 0.432 | 94.3 | PPAT,GLUD1,GPT2 |
 | RNA polymerase | 1.96 | 0.0032 | 2.36 | 0.022 | 93.3 | POLR2E,POLR3H,POLR2B,POLR2J,POLR2D, POLR3K,POLR1B,POLR1A |
 | Basal transcription factors | 2.48 | 0.0002 | 1.49 | 0.580 | 91.6 | GTF2F1,TAF4,GTF2A1L,TAF11 |
BIOCARTA | Cyclins and Cell Cycle Regulation | 1.92 | 0.0127 | 3.17 | 0.029 | 91.7 | CCNA1,CDKN2C,CCNB1,CDC25A,TFDP1,CDK4 |
 | Proteasome Complex | 1.71 | 0.0053 | 1.57 | 0.274 | 79.1 | PSMB7,PSMA7,PSMD14,PSMB2 |