Fig. 4

Schematic diagrams of prognosis-related signaling pathways with representative genes and targeted agents. a, Prognostic signaling pathways identified in SHH subgroup. b, Prognostic signaling pathways identified in Group 3. c, Prognostic signaling pathways identified in Group 4. The genes in colored boxes indicate prognosis-related genes detected in SHH (red), Group 3(orange), or Group 4 (green). The genes in the white boxes are linker genes included to connect the signaling pathways. Representative targeted agents in clinical, preclinical or early-phase development are presented. Colored arrow denotes relatively high or low expression of the gene in SHH (red), Group 3(orange), or Group 4 (green) and the detailed boxplot of the gene expression is presented in Additional file 2: Figures S3, S4, or S6. Fc receptors, FCER1G and FCGR2A/B in core gene list of Group 4, Integrins, ITGB1/2 in core gene list of Group 4