Table 2 Univariate and multivariate analyses for overall survival (OS) including pre-operatively known parameters as well as FBXO11 in 222 RCC patients treated with surgery
Overall Survival | Training cohort (150 patients) | Validation cohort (77 patients) | ||||||
|---|---|---|---|---|---|---|---|---|
Univariate analysis | Multivariate analysis | Univariate analysis | Multivariate analysis | |||||
HR | p Value | HR | p Value | HR | p Value | HR | p Value | |
Gender | 0.500 (0.219–1.142) | 0.100 | – | – | 0.956 (0.428–2.135) | 0.913 | – | – |
Age | 1.664 (0.851–3.253) | 0.136 | – | – | 1.554 (0.680–3.554) | 0.296 | – | – |
Tumor size | 1.606 (1.037–2.489) | 0.034 | 1.276 (0.771–2.113) | 0.343 | 1.461 (0.811–2.635) | 0.207 | 1.267 (0.665–2.414) | 0.471 |
FBXO11 | 2.817 (1.323–5.997) | 0.007 | 2.381 (1.089–5.205) | 0.030 | 5.740 (1.951–16.891) | 0.002 | 4.075 (1.280–12.971) | 0.017 |
Fuhrman grade | 1.639 (1.045–2.568) | 0.031 | 0.913 (0.533–1.563) | 0.740 | 1.964 (1.206–3.198) | 0.007 | 1.178 (0.708–1.960) | 0.529 |
Pathologic stage | 1.730 (1.089–2.747) | 0.020 | 0.570 (0.243–1.338) | 0.197 | 1.470 (0.971–2.226) | 0.069 |  |  |
Lymph node status | 3.013 (0.723–12.557) | 0.130 |  |  | 2.571 (0.873–7.577) | 0.087 |  |  |
Distant metastasis | 1.732 (0.237–12.644) | 0.588 | – | – | 3.246 (0.961–10.961) | 0.058 | – | – |
Sarcomatoid | 1.776 (0.628–5.028) | 0.279 | – | – | 1.292 (0.303–5.499) | 0.729 | – | – |
Type of surgery | 1.366 (0.692–2.696) | 0.369 |  |  | 1.351 (0.600–3.042) | 0.468 |  |  |
UISS score system | 2.316 (1.489–3.601) | 0.001 | 2.766 (1.139–6.713) | 0.025 | 5.821 (2.604–13.015) | 0.001 | 2.781 (1.059–7.300) | 0.038 |
SSIGN score system | 2.174 (1.240–3.812) | 0.007 | 1.240 (0.503–3.061) | 0.640 | 2.318 (1.404–3.826) | 0.001 | 1.565 (0.774–3.163) | 0.212 |