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Fig. 5 | BMC Cancer

Fig. 5

From: Aberrantly expressed miR-188-5p promotes gastric cancer metastasis by activating Wnt/β-catenin signaling

Fig. 5

miR-188-5p activates Wnt/β-catenin signaling through PTEN-Akt-GSK3β cascades. a Luciferase assay of the 3′ UTR activity of PTEN in the indicated cells transfected with the indicated TSB. b Assay of TOP/FOP luciferase activity in the indicated cells. c Western blotting analyses of PTEN, Akt, p-Akt (Ser473), GSK3β and p-GSK3β (Ser9) expression in the indicated cells. Error bars represent mean ± SD from three independent experiments.**, P < 0.01; *, P < 0.05. NC, normal control; qPCR; quantitative real-time PCR; PTEN, phosphatase and tensin homolog; TSB, target site blocker; UTR, untranslated region

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BMC Cancer

ISSN: 1471-2407

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