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Table 5 Characteristics of “adaptive” or “non-adaptive” patients

From: Fluoropyrimidine with or without platinum as first-line chemotherapy in patients with advanced gastric cancer and severe peritoneal metastasis: a multicenter retrospective study

Characteristics

Adaptive patients

Non-adaptive patients

p-value

(n = 101)

(n = 28)

No. (%)

No. (%)

Age (years)

 Median (range)

65 (24–86)

67 (34–94)

0.09

Sex

 Male

51 (50)

17 (61)

0.34

 Female

50 (50)

11 (39)

 

ECOG PS

 0

8 (8)

1 (4)

 

 1

56 (55)

12 (43)

 

 2

32 (32)

12 (43)

 

 3

4 (4)

3 (11)

 

 4

1 (1)

0 (0)

 

 0–1

64 (63)

13 (46)

0.11

 2–4

37 (37)

15 (54)

 

Disease status

 Advanced

92 (91)

28 (100)

0.10

 Recurrent

9 (9)

0 (0)

 

Primary site

 Stomach

97 (96)

26 (93)

0.48

 GEJ

4 (4)

2 (7)

 

No. of metastatic sites

 1–2

81 (80)

19 (68)

0.17

> 3

20 (20)

9 (32)

 

Subtype of SPM

 Massive ascites

46 (45)

16 (57)

0.50

 Inadequate oral intake

28 (27)

7 (25)

 

 Both

27 (27)

5 (18)

 

Serum albumin level (g/ml)

 Median (range)

3.1 (1.8–4.4)

2.9 (2.0–4.2)

0.13

Serum CRP level (mg/dl)

 Median (range)

1.6 (0.0–20.7)

4.8 (0.1–24.0)

< 0.01

  1. Patients who died within 90 days after treatment initiation were defined as “non-adaptive”
  2. Other patients were defined as “adaptive”
  3. CRP C-reactive protein, ECOG PS Eastern Cooperative Oncology Group performance status, GEJ gastroesophageal junction, SPM severe peritoneal metastasis