Table 3 Univariate and multivariate analyses of the prognostic factors of PFS in AGC patients with SPM (n = 129)
Variables | Univariate analysis | Multivariate analysis | ||||
|---|---|---|---|---|---|---|
HR | [95% CI] | p-value | HR | [95% CI] | p-value | |
Regimen | ||||||
FP (vs. F) | 0.44 | [0.30–0.66] | < 0.01 | 0.41 | [0.26–0.64] | < 0.01 |
Age | ||||||
≥65 (vs. < 65) | 0.99 | [0.67–1.45] | 0.95 | |||
Sex | ||||||
Female (vs. male) | 0.96 | [0.65–1.41] | 0.82 | |||
ECOG PS | ||||||
2–4 (vs. 0–1) | 1.28 | [0.86–1.90] | 0.22 | 1.04 | [0.68–1.60] | 0.86 |
Histology | ||||||
Intestinal (vs. diffuse) | 0.81 | [0.48–1.39] | 0.45 | |||
Unknown (vs. diffuse) | NA | NA | ||||
Disease status | ||||||
Recurrent (vs. advanced) | 0.48 | [0.20–1.19] | 0.11 | 0.60 | [0.24–1.50] | 0.27 |
Primary site | ||||||
GEJ (vs. stomach) | 0.55 | [0.20–1.53] | 0.25 | |||
No. of metastatic sites | ||||||
≥3 (vs. 1–2) | 1.28 | [0.86–1.90] | 0.22 | |||
Target lesion | ||||||
Absence (vs. presence) | 1.03 | [0.69–1.53] | 0.90 | |||
Subtype of SPM | ||||||
Inadequate oral intake (vs. massive ascites) | 0.66 | [0.41–1.07] | 0.09 | 0.64 | [0.40–1.04] | 0.07 |
Both (vs. massive ascites) | 0.88 | [0.54–1.44] | 0.61 | 0.57 | [0.34–0.96] | 0.03 |
Serum albumin level | ||||||
< 3.1 g/ml (vs. > 3.1 g/ml) | 1.10 | [0.74–1.62] | 0.65 | |||