Category/treatment | N | 5-year CI | 10-year CI | p-value | |||
---|---|---|---|---|---|---|---|
PE | 95% CI | PE | 95% CI | ||||
Overall | 5311 | 7.2 | [6.5, 7.9] | 11.3 | [10.4, 12.3] | ||
Age | < 70 years | 3714 | 7.8 | [7.0, 8.7] | 12.5 | [11.4, 13.7] | < 0.001 |
≥ 70 years | 1597 | 5.8 | [4.7, 7.0] | 8.6 | [7.2, 10.2] | ||
Clinical stage | T1/2N0 | 2918 | 3.6 | [3.0, 4.4] | 6.0 | [5.1, 7.0] | < 0.001 |
T1/2N+ | 1613 | 10.8 | [9.4, 12.4] | 17.5 | [15.6, 19.7] | ||
T3/4N0 | 124 | 11.3 | [6.9, 18.6] | 16.6 | [10.9, 25.4] | ||
T3/4N+ | 409 | 19.6 | [16.1, 23.8] | 27.3 | [23.0, 32.4] | ||
missing | 247 | 3.3 | [1.6, 6.5] | 4.3 | [2.3, 7.9] | ||
Morphology | invasive ductal | 3690 | 7.6 | [6.8, 8.5] | 11.5 | [10.4, 12.7] | 0.085 |
invasive lobular | 758 | 6.6 | [5.1, 8.7] | 12.4 | [10.1, 15.4] | ||
mixed type | 459 | 6.3 | [4.5, 9.0] | 11.3 | [8.6, 15.0] | ||
other | 404 | 5.3 | [3.5, 8.0] | 7.0 | [4.8, 10.2] | ||
Histopathologic grade | 1 | 447 | 1.4 | [0.6, 3.0] | 3.9 | [2.3, 6.6] | < 0.001 |
2 | 3332 | 5.8 | [5.0, 6.6] | 9.8 | [8.7, 10.9] | ||
3/4 | 1497 | 12.1 | [10.5, 13.8] | 17.0 | [15.1, 19.1] | ||
missing | 35 | 9.0 | [3.0, 26.9] | 9.0 | [3.0, 26.9] | ||
HR expression | positive a | 4132 | 5.6 | [5.0, 6.4] | 10.0 | [9.0, 11.0] | < 0.001 |
negative | 775 | 15.9 | [13.5, 18.7] | 19.0 | [16.4, 22.1] | ||
missing | 404 | 6.3 | [4.3, 9.1] | 9.8 | [7.0, 13.8] | ||
HER2/neu expression | positive b | 972 | 9.1 | [7.4, 11.1] | 15.1 | [12.8, 17.8] | 0.001 |
negative | 2941 | 6.6 | [5.7, 7.5] | 9.8 | [8.7, 11.0] | ||
missing | 1398 | 7.2 | [6.0, 8.7] | 11.6 | [9.9, 13.5] | ||
Subtype based on immunohistochemical surrogates | ’HR positive‘ | 4132 | 5.6 | [5.0, 6.4] | 10.0 | [9.0, 11.0] | < 0.001 |
‚HER2/neu positive‘c | 234 | 15.9 | [11.8, 21.4] | 19.4 | [14.7, 25.5] | ||
‚triple negative‘d | 376 | 16.3 | [12.9, 20.5] | 18.7 | [15.0, 23.2] | ||
missing | 569 | 8.9 | [6.8, 11.5] | 12.6 | [10.0, 15.9] | ||
BCS | T1/2N0 | 198 | 3.1 | [1.4, 6.7] | 4.4 | [2.2, 8.7] | |
BCS + RT | T1/2N0 | 2114 | 3.0 | [2.4, 3.9] | 5.4 | [4.5, 6.6] | |
Mastectomy | T1/2N0 | 606 | 5.8 | [4.2, 8.0] | 8.2 | [6.2, 10.8] | |
(BCS + RT or mastectomy) + HT | T1/2N0 HR positive a | 1749 | 2.7 | [2.0, 3.6] | 5.2 | [4.2, 6.5] | |
(BCS + RT or mastectomy) + CT | T1/2N0 HR negative | 277 | 7.9 | [5.3, 11.9] | 9.2 | [6.3, 13.4] | |
(BCS + RT or mastectomy) + HT (if HR positive) + CT (if HR negative) + TT | T1/2N0 HER2/neu positive | 73 | 2.7 | [0.7, 10.9] | 2.7 | [0.7, 10.9] | |
(BCS or mastectomy) + RT + CT + HT | T1/2N+ HR positive a | 554 | 8.6 | [6.5, 11.3] | 15.4 | [12.2, 19.3] | |
(BCS or mastectomy) + RT + CT | T1/2N+ HR negative | 156 | 23.2 | [17.4, 31.0] | 30.7 | [23.9, 39.4] | |
(BCS or mastectomy) + RT + CT + HT (if HR positive) + TT | T1/2N+ HER2/neu positive | 51 | 13.7 | [6.8, 27.5] | 16.0 | [8.4, 30.5] | |
MAST + RT + CT + HT | T3/4 HR positive a | 88 | 14.8 | [8.9, 24.5] | 24.1 | [15.8, 36.8] | |
MAST + RT + CT | T3/4 HR negative | 50 | 40.0 | [28.3, 56.5] | 40.0 | [28.3, 56.5] |