Category | Study sample | Patients with a local R0 resection, available follow-up and without recurrence within 3 months | |||
---|---|---|---|---|---|
N | % a | N | % a | ||
Overall | 8518 | 5311 | |||
Age | < 70 years | 5725 | 67.2 | 3714 | 69.9 |
≥ 70 years | 2793 | 32.8 | 1597 | 30.1 | |
Laterality | available | 8508 | 99.9 | 5307 | 99.9 |
unilateral | 8306 | 97.6 | 5198 | 97.9 | |
synchronous bilateral b | 202 | 2.4 | 109 | 2.1 | |
Clinical stage | available | 7447 | 87.4 | 5064 | 95.3 |
T1/2N0 | 4132 | 55.5 | 2918 | 57.6 | |
T1/2N+ | 2379 | 31.9 | 1613 | 31.9 | |
T3/4N0 | 205 | 2.8 | 124 | 2.4 | |
T3/4N+ | 731 | 9.8 | 409 | 8.1 | |
Microscopically verified | 8482 | 99.6 | 5311 | 100.0 | |
Morphology | available | 8477 | 99.5 | 5311 | 100.0 |
invasive ductal | 5883 | 69.4 | 3690 | 69.5 | |
invasive lobular | 1190 | 14.0 | 758 | 14.3 | |
mixed type | 654 | 7.7 | 459 | 8.6 | |
other | 750 | 8.8 | 404 | 7.6 | |
Histopathologic grade | available | 8216 | 96.5 | 5376 | 99.3 |
1 | 610 | 7.4 | 447 | 8.5 | |
2 | 5232 | 63.7 | 3332 | 63.2 | |
3/4 | 2374 | 28.9 | 1497 | 28.4 | |
HR expression | available | 7424 | 87.2 | 4907 | 92.4 |
positive c | 6235 | 84.0 | 4132 | 84.2 | |
negative | 1189 | 16.0 | 775 | 15.8 | |
HER2/neu expression | available | 5938 | 69.7 | 3913 | 73.7 |
positive d | 1466 | 24.7 | 972 | 24.8 | |
negative | 4472 | 75.3 | 2941 | 75.2 | |
Subtype based on immunohistochemical surrogates | HR and HER2/neu status available | 7197 | 84.5 | 4742 | 89.3 |
’HR positive‘ | 6235 | 86.6 | 4132 | 87.1 | |
‚HER2/neu positive‘e | 368 | 5.1 | 234 | 4.9 | |
‚triple negative‘f | 594 | 8.3 | 376 | 7.9 | |
Follow-up available | 8380 | 98.4 | 5311 | 100.0 | |
years | years | ||||
Mean observation time | 10.3 | 10.2 |