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Table 3 Sensitivity Analysis

From: Accuracy of analysis of cfDNA for detection of single nucleotide variants and copy number variants in breast cancer

SNV

(ABC)

Author(Study)

Year

Sensitivity

Heterogeneity (I2, p value)

Specificity

Heterogeneity (I2, p value)

 

Board RE.2010(2)

2010

0.774(0.715–0.818)

40.6%, 0.021

0.894(0.871–0.923)

53.1%, 0.001

Chung.JH.2017

2017

0.772(0.720–0.819)

38.3%, 0.031

0.898(0.876–0.922)

55.4%, 0.001

Chung.JH.2017(2)

2017

0.771(0.719–0.818)

36.4%, 0.035

0.905(0.878–0.927)

54.9%, 0.001

Chung.JH.2017(3)

2017

0.774(0.716–0.818)

40.6%, 0.024

0.906(0.880–0.929)

53.4%, 0.000

Dawson SJ.2013

2013

0.770(0.717–0.817)

38.9%, 0.028

0.895(0.867–0.919)

51.3%, 0.002

Dawson SJ.2013(2)

2013

0.760(0.704–0.810)

34.0%, 0.054

0.896(0.88–0.920)

52.6%, 0.001

Frenel JS.2015

2015

0.773(0.721–0.818)

39.8%, 0.024

0.898(0.870–0.922)

54.2%, 0.001

Frenel JS.2015(2)

2015

0.777(0.724–0.823)

40.1%, 0.031

0.899(0.871–0.922)

55.2%, 0.000

Garcia-Saenz JA.2015

2015

0.773(0.719–0.821)

39.4%, 0.026

0.896(0.876–0.926)

59.5%, 0.000

Garcia-Saenz JA.2015(2)

2015

0.780(0.728–0.827)

36.4%, 0.040

0.897(0.869–0.922)

55.2%, 0.000

Higgins MJ.2011

2011

0.777(0.722–0.825)

37.4%, 0.034

0.902(0.875–0.925)

59.5%, 0.000

Higgins MJ.2012

2012

0.763(0.709–0.808)

25.2%, 0.129

0.914(0.892–0.939)

43.9%, 0.012

Janku. F.2015

2015

0.780(0.726–0.825)

39.0%, 0.027

0.912(0.886–0.934)

42.7%, 0.001

Liang DH.2016

2016

0.770(0.717–0.815)

38.8%, 0.028

0.896(0.865–0.926)

55.1%, 0.000

Liang DH.2016(2)

2016

0.777(0.719–0.821)

39.4%, 0.026

0.897(0.875–0.925)

55.4%, 0.000

Madic.J.2015

2015

0.787(0.729–0.831)

32.3%, 0.066

0.899(0.871–0.926)

55.4%, 0.000

Nakauchi.C.2016

2016

0.771(0.717–0.820)

39.5%, 0.025

0.900(0.872–0.923)

55.0%, 0.001

Nakauchi.C.2016(2)

2016

0.775(0.717–0.819)

39.9%, 0.024

0.904(0.877–0.927)

55.1%, 0.000

Rothe F.2014

2014

0.777(0.719–0.821)

39.4%, 0.026

0.899(0.871–0.926)

55.4%, 0.001

Rothe F.2014(2)

2014

0.777(0.719–0.821)

39.4%, 0.026

0.898(0.875–0.925)

55.1%, 0.001

Schiavon.G.2015

2015

0.773(0.721–0.820)

40.5%, 0.022

0.896(0.867–0.920)

52.2%, 0.000

Sefrioui.D.2015

2015

0.775(0.723–0.821)

40.7%, 0.021

0.894(0.85–0.918)

49.6%, 0.003

Spoerke J.2016

2016

0.779(0.727–0.826)

38.6%, 0.034

0.896(0.874–0.924)

52.6%, 0.001

Takeshita.T.2017

2017

0.787(0.712–0.825)

19.3%, 0.021

0.901(0.867–0.927)

55.3%, 0.001

Kodahl AR.2018

2018

0.769(0.715–0.818)

39.8%, 0.024

0.898(0.878–0.928)

54.4%, 0.001

CNV

Author(Study)

Year

Sensitivity

Heterogeneity (I2, p value)

Specificity

Heterogeneity (I2, p value)

 

Chung.JH.2017(4)

2017

0.474(0.244–0.711)

0.00%, 0.499

0.966(0.883–0.996)

29.6%, 0.235

Chung.JH.2017(5)

2017

0.391(0.197–0.615)

0.00%, 0.600

0.964(0.875–0.996)

24.5%, 0.264

Liang DH.2016(3)

2016

0.381(0.181–0.616)

0.00%, 0.422

0.958(0.857–0.995)

12.3%, 0.331

Liang DH.2016(4)

2016

0.409(0.207–0.636)

17.1%, 0.305

1.000(0.925–1.000)

0.00%, 1.000

Page.K.2011

2011

0.455(0.167–0.766)

15.8%, 0.210

0.968(0.890–0.996)

33.7%, 0.210