Skip to main content

Advertisement

Table 3 Sensitivity Analysis

From: Accuracy of analysis of cfDNA for detection of single nucleotide variants and copy number variants in breast cancer

SNV (ABC) Author(Study) Year Sensitivity Heterogeneity (I2, p value) Specificity Heterogeneity (I2, p value)
  Board RE.2010(2) 2010 0.774(0.715–0.818) 40.6%, 0.021 0.894(0.871–0.923) 53.1%, 0.001
Chung.JH.2017 2017 0.772(0.720–0.819) 38.3%, 0.031 0.898(0.876–0.922) 55.4%, 0.001
Chung.JH.2017(2) 2017 0.771(0.719–0.818) 36.4%, 0.035 0.905(0.878–0.927) 54.9%, 0.001
Chung.JH.2017(3) 2017 0.774(0.716–0.818) 40.6%, 0.024 0.906(0.880–0.929) 53.4%, 0.000
Dawson SJ.2013 2013 0.770(0.717–0.817) 38.9%, 0.028 0.895(0.867–0.919) 51.3%, 0.002
Dawson SJ.2013(2) 2013 0.760(0.704–0.810) 34.0%, 0.054 0.896(0.88–0.920) 52.6%, 0.001
Frenel JS.2015 2015 0.773(0.721–0.818) 39.8%, 0.024 0.898(0.870–0.922) 54.2%, 0.001
Frenel JS.2015(2) 2015 0.777(0.724–0.823) 40.1%, 0.031 0.899(0.871–0.922) 55.2%, 0.000
Garcia-Saenz JA.2015 2015 0.773(0.719–0.821) 39.4%, 0.026 0.896(0.876–0.926) 59.5%, 0.000
Garcia-Saenz JA.2015(2) 2015 0.780(0.728–0.827) 36.4%, 0.040 0.897(0.869–0.922) 55.2%, 0.000
Higgins MJ.2011 2011 0.777(0.722–0.825) 37.4%, 0.034 0.902(0.875–0.925) 59.5%, 0.000
Higgins MJ.2012 2012 0.763(0.709–0.808) 25.2%, 0.129 0.914(0.892–0.939) 43.9%, 0.012
Janku. F.2015 2015 0.780(0.726–0.825) 39.0%, 0.027 0.912(0.886–0.934) 42.7%, 0.001
Liang DH.2016 2016 0.770(0.717–0.815) 38.8%, 0.028 0.896(0.865–0.926) 55.1%, 0.000
Liang DH.2016(2) 2016 0.777(0.719–0.821) 39.4%, 0.026 0.897(0.875–0.925) 55.4%, 0.000
Madic.J.2015 2015 0.787(0.729–0.831) 32.3%, 0.066 0.899(0.871–0.926) 55.4%, 0.000
Nakauchi.C.2016 2016 0.771(0.717–0.820) 39.5%, 0.025 0.900(0.872–0.923) 55.0%, 0.001
Nakauchi.C.2016(2) 2016 0.775(0.717–0.819) 39.9%, 0.024 0.904(0.877–0.927) 55.1%, 0.000
Rothe F.2014 2014 0.777(0.719–0.821) 39.4%, 0.026 0.899(0.871–0.926) 55.4%, 0.001
Rothe F.2014(2) 2014 0.777(0.719–0.821) 39.4%, 0.026 0.898(0.875–0.925) 55.1%, 0.001
Schiavon.G.2015 2015 0.773(0.721–0.820) 40.5%, 0.022 0.896(0.867–0.920) 52.2%, 0.000
Sefrioui.D.2015 2015 0.775(0.723–0.821) 40.7%, 0.021 0.894(0.85–0.918) 49.6%, 0.003
Spoerke J.2016 2016 0.779(0.727–0.826) 38.6%, 0.034 0.896(0.874–0.924) 52.6%, 0.001
Takeshita.T.2017 2017 0.787(0.712–0.825) 19.3%, 0.021 0.901(0.867–0.927) 55.3%, 0.001
Kodahl AR.2018 2018 0.769(0.715–0.818) 39.8%, 0.024 0.898(0.878–0.928) 54.4%, 0.001
CNV Author(Study) Year Sensitivity Heterogeneity (I2, p value) Specificity Heterogeneity (I2, p value)
  Chung.JH.2017(4) 2017 0.474(0.244–0.711) 0.00%, 0.499 0.966(0.883–0.996) 29.6%, 0.235
Chung.JH.2017(5) 2017 0.391(0.197–0.615) 0.00%, 0.600 0.964(0.875–0.996) 24.5%, 0.264
Liang DH.2016(3) 2016 0.381(0.181–0.616) 0.00%, 0.422 0.958(0.857–0.995) 12.3%, 0.331
Liang DH.2016(4) 2016 0.409(0.207–0.636) 17.1%, 0.305 1.000(0.925–1.000) 0.00%, 1.000
Page.K.2011 2011 0.455(0.167–0.766) 15.8%, 0.210 0.968(0.890–0.996) 33.7%, 0.210