Table 2 Meta-analysis Estimates
SNV(Stage) | P Sen (95% CI) | Heterogeneity (I2, p value) | P Spe (95% CI) | Heterogeneity(I2,p value) | PLR (95% CI) | NLR (95% CI) | DOR | AUC (SROC) | ADT (SCC, p) |
|---|---|---|---|---|---|---|---|---|---|
Overall | 0.79(0.69–0.87) | 50.0%, 0.00 | 0.94(0.90–0.97) | 67.8%, 0.000 | 13.8(7.8–24.5) | 0.22(0.15–0.34) | 62(29–133) | 0.95(0.92–0.96) | 0.08, 0.5 |
EBC | 0.79(0.04–1.00) | 92.99%, 0.00 | 1.00(0.47–1.00) | 93.30%, 0.000 | 1104.9(1.3–958,356.8) | 0.21(0.01–7.30) | 5174(22–1,242,093) | 1.00(0.99–1.00) | 1.00, 0.00 |
ABC | 0.78(0.71–0.84) | 35.72%, 0.04 | 0.92(0.87–0.95) | 55.64%, 0.001 | 10.3(6.6–16.2) | 0.24(0.18–0.32) | 40(21–75) | 0.91(0.88–0.93) | 0.02, 092 |
ABC* | 0.77(0.70–0.83) | 28.6%, 0.10 | 0.93(0.90–0.95) | 2.81%, 0.42 | 10.5(7.3–15.0) | 0.25(0.18–0.34) | 42(24–75) | 0.94(0.92–0.96) | −0.09, 0.69 |
SNV(Gene) | |||||||||
PIK3CA | 0.83(0.68–0.91) | 29.9%,0.12 | 0.95(0.90–0.98) | 78.2%,0.000 | 15.5(7.6–31.5) | 0.18(0.10–0.36) | 84(33–219) | 0.96(0.94–0.98) | 0.23, 0.37 |
PIK3CA(EBC) | 0.79(0.04–1.00) | 92.99%, 0.00 | 1.00(0.47–1.00) | 93.30%, 0.000 | 1104.9(1.3–958,356.8) | 0.21(0.01–7.30) | 5174(22–1,242,093) | 1.00(0.99–1.00) | 1.00, 0.00 |
PIK3CA(ABC) | 0.80(0.74–0.85) | 0.00%,0.45 | 0.91(0.86–0.96) | 65.18%,0.00 | 9.0(5.3–15.5) | 0.22(0.17–0.29) | 41(21–80) | 0.83(0.79–0.86) | 0.35, 0.25 |
PIK3CA(ABC)a | 0.80(0.73–0.85) | 0.00%,0.78 | 0.93(0.90–0.95) | 0.00%,0.91 | 11.1(7.6–16.1) | 0.22(0.16–0.30) | 50(29–88) | 0.94(0.91–0.96) | 0.10, 0.75 |
TP53 | 0.78(0.64–0.88) | 39.72%,0.13 | 0.92(0.81–0.97) | 3.56%,0.40 | 10.3(3.9–27.8) | 0.24(0.13–0.42) | 44(11–169) | 0.94(0.91–0.95) | 0.09, 0.87 |
ESR1 | 0.56(0.30–0.79) | 45.67%, 0.14 | 0.95(0.69–0.99) | 72.84%, 0.01 | 10.8(1.3–89.7) | 0.47(0.25–0.88) | 23(2–282) | 0.80(0.76–0.83) | −0.05, 0.94 |
CNV | P Sen (95% CI) | Heterogeneity (I2,p value) | P Spe (95% CI) | Heterogeneity(I2,p value) | PLR (95% CI) | NLR (95% CI) | DOR | AUC (SROC) | ADT (SCC, p) |
|  | 0.42 (0.24–0.62) | 0.0%,0.52 | 0.98(0.71–1.00) | 13.27%, 0.33 | 19.9(1.1–365.1) | 0.60(0.42–0.84) | 33(2–702) | 0.45(0.41–0.50) | −0.50, 0.39 |