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Table 2 Meta-analysis Estimates

From: Accuracy of analysis of cfDNA for detection of single nucleotide variants and copy number variants in breast cancer

SNV(Stage) P Sen (95% CI) Heterogeneity (I2, p value) P Spe (95% CI) Heterogeneity(I2,p value) PLR (95% CI) NLR (95% CI) DOR AUC (SROC) ADT (SCC, p)
Overall 0.79(0.69–0.87) 50.0%, 0.00 0.94(0.90–0.97) 67.8%, 0.000 13.8(7.8–24.5) 0.22(0.15–0.34) 62(29–133) 0.95(0.92–0.96) 0.08, 0.5
EBC 0.79(0.04–1.00) 92.99%, 0.00 1.00(0.47–1.00) 93.30%, 0.000 1104.9(1.3–958,356.8) 0.21(0.01–7.30) 5174(22–1,242,093) 1.00(0.99–1.00) 1.00, 0.00
ABC 0.78(0.71–0.84) 35.72%, 0.04 0.92(0.87–0.95) 55.64%, 0.001 10.3(6.6–16.2) 0.24(0.18–0.32) 40(21–75) 0.91(0.88–0.93) 0.02, 092
ABC* 0.77(0.70–0.83) 28.6%, 0.10 0.93(0.90–0.95) 2.81%, 0.42 10.5(7.3–15.0) 0.25(0.18–0.34) 42(24–75) 0.94(0.92–0.96) −0.09, 0.69
SNV(Gene)
PIK3CA 0.83(0.68–0.91) 29.9%,0.12 0.95(0.90–0.98) 78.2%,0.000 15.5(7.6–31.5) 0.18(0.10–0.36) 84(33–219) 0.96(0.94–0.98) 0.23, 0.37
PIK3CA(EBC) 0.79(0.04–1.00) 92.99%, 0.00 1.00(0.47–1.00) 93.30%, 0.000 1104.9(1.3–958,356.8) 0.21(0.01–7.30) 5174(22–1,242,093) 1.00(0.99–1.00) 1.00, 0.00
PIK3CA(ABC) 0.80(0.74–0.85) 0.00%,0.45 0.91(0.86–0.96) 65.18%,0.00 9.0(5.3–15.5) 0.22(0.17–0.29) 41(21–80) 0.83(0.79–0.86) 0.35, 0.25
PIK3CA(ABC)a 0.80(0.73–0.85) 0.00%,0.78 0.93(0.90–0.95) 0.00%,0.91 11.1(7.6–16.1) 0.22(0.16–0.30) 50(29–88) 0.94(0.91–0.96) 0.10, 0.75
TP53 0.78(0.64–0.88) 39.72%,0.13 0.92(0.81–0.97) 3.56%,0.40 10.3(3.9–27.8) 0.24(0.13–0.42) 44(11–169) 0.94(0.91–0.95) 0.09, 0.87
ESR1 0.56(0.30–0.79) 45.67%, 0.14 0.95(0.69–0.99) 72.84%, 0.01 10.8(1.3–89.7) 0.47(0.25–0.88) 23(2–282) 0.80(0.76–0.83) −0.05, 0.94
CNV P Sen (95% CI) Heterogeneity (I2,p value) P Spe (95% CI) Heterogeneity(I2,p value) PLR (95% CI) NLR (95% CI) DOR AUC (SROC) ADT (SCC, p)
  0.42 (0.24–0.62) 0.0%,0.52 0.98(0.71–1.00) 13.27%, 0.33 19.9(1.1–365.1) 0.60(0.42–0.84) 33(2–702) 0.45(0.41–0.50) −0.50, 0.39
  1. Note: a, Studies of Higgins MJ.2011 and Higgins MJ. 2012 were excluded
  2. Abbreviation: P Sen Pooled Sensitivity, CI confidence interval, P Spe Pooled Specificity, PLR Positive Likelihood Ratio, NLR Negative Likelihood Ratio, DOR Diagnostic Odds Ratio, AUC Area Under Curve, ADT Analysis of Diagnostic Threshold, SCC Spearman correlation coefficient, EBC Early breast cancer, ABC Advanced breast cancer