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Table 2 Risk of thyroid disorders among head and neck cancer patients who received various surgical procedures stratified by primary tumor site

From: Subsequent thyroid disorders associated with treatment strategy in head and neck cancer patients: a nationwide cohort study

  All neck cancers Oral cancer Salivary gland cancer Oropharyngeal, hypopharyngeal, and pharyngeal cancer Cancers in unspecified sites
PTE + ND
(N = 7460)
PTE
(N = 3730)
PTE + ND
(N = 3530)
PTE
(N = 1237)
PTE + ND
(N = 85)
PTE
(N = 453)
PTE + ND
(N = 413)
PTE
(N = 596)
PTE + ND
(N = 3422)
PTE
(N = 1444)
N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%) N (%)
Thyroid disorders 122 (1.64) 50 (1.34) 65 (1.84) 20 (1.62) 1 (1.18) 8 (1.77) 22 (5.33) 10 (1.68) 34 (0.99) 12 (0.83)
Crude HR 1.16 (0.83–1.61) 1 1.15 (0.70–1.90) 1 0.74 (0.09–5.94) 1 1.59 (0.75–3.36) 1 1.19 (0.62–2.30) 1
Adjusted HR 1.21 (0.87–1.68) 1 1.08 (0.65–1.78) 1 0.69 (0.09–5.52) 1 1.50 (0.67–3.38) 1 1.22 (0.63–2.35) 1
CRR 1.25 (0.90–1.74) 1 1.10 (0.67–1.82) 1 0.66 (0.08–5.23) 1 2.81 (1.37–5.75)* 1 1.17 (0.61–2.27) 1
  1. PTE primary tumor excision, ND neck dissection, HR hazard ratio, CRR competing risks regression
  2. *P < 0.05