Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma

BMC Cancer

Table 3 Cox Regression of morphometric vitronectin variables and INRG prognostic factors

Variable	B	S.E	Wald	Exp (B) (95% CI)	p-value
EFS
Age (≥18 month)	1.361	0.526	6.696	3.898 (1.39–10.92)	0.010
Hist.D (uNB/pdNB)	1.073	0.411	6.806	2.924 (1.30–6.54)	0.009
11q status (11qD)	0.883	0.424	4.332	2.418 (1.05–5.55)	0.037
OS
Age (≥18 month)	1.320	0.603	4.797	3.745 (1.14–12.20)	0.029
11q status (11qD)	1.309	0.469	7.785	3.702 (1.47–9.28)	0.005
*MYCN (MNA)	0.857	0.472	3.296	2.357 (0.94–5.94)	0.069
*Terr. VN_Q₃	0.852	0.480	3.154	2.344 (0.92–6)	0.076

Significant INRG prognostic parameters and morphometric vitronectin (VN) measurements predictive of poor outcome in neuroblastoma (NB) patients based on event-free survival (EFS) and overall survival (OS) with p-value < 0.05 and *p-value < 0.1. Hist.D: histopathologic differentiation; uNB: undifferentiated neuroblastoma; pdNB: poorly differentiated neuroblastoma; 11qD: 11q deletion; MNA: MYCN amplified; Terr.VN_Q₃: Territorial vitronectin dichotomized at the third quartile. B: Beta coefficient; S.E: Standard Error; CI: Confidence interval. Coefficients Exp (B) > 1 indicate that high values of this parameter increase the probability of it being an independent poor prognostic factor

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