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Table 2 p-values and relationship between vitronectin and nuclei morphometric measurements and poor prognostic factors

From: Vitronectin as a molecular player of the tumor microenvironment in neuroblastoma

Parameter

Age: ≥18 months

Stage: M

Hist.D: uNB/pdNB

MYCN: MNA

Gen. profile: SCA

11q: 11qD

Risk group: high-risk

Gen. Instab.:High

IPP

Nuclei

Dens.

0.005↑

0.007↑

0.001↑

0.001↑

0.003↑

%SA

0.004↑

0.018↓

Inter.VN

%SA

Terr.VN

%SA

0.010↑

0.001↑*

0.024↑

0.001↑

0.035↑

0.008↑

0.000↑

Densito

VN ratio of pixels

Weak

Mod.

Strong

0.037↑

0.010↑*

0.011↑

0.002↑

0.021↑

0.004↑

0.010 ↑

H-score

0.019↑

0.040↑

0.011↑

0.008↑

0.001↑

  1. Only morphometric variables for vitronectin (VN) expression and nuclei having a statistically significant relationship with pre-treatment risk stratification factors are shown (p-value< 0.05). IPP: Image Pro-Plus; Densito: DensitoQuant; Dens. Density (number of objects/mm2); %SA: percentage of stained area; Inter. VN: Interterritorial VN; Terr.VN: Territorial VN; Mod.: moderate. M: metastatic; Hist.D: histopathologic differentiation; uNB: undifferentiated neuroblastoma; pdNB: poorly differentiated neuroblastoma; NOS was excluded from statistical analysis; Gen. Profile: genetic profile; SCA: segmental chromosomal aberration; MNA: MYCN amplified; 11qD: 11q deletion; Gen. Instab.: genetic instability. -: not statistically significant, ↑/↓: higher or lower median value for the poor-prognostic group(s). *There are statistically significant differences between pdNB and uNB, within Strong VN (p-value< 0.05) and %SA Territorial VN (p-value< 0.1) morphometric variables