Parameter | Age: ≥18 months | Stage: M | Hist.D: uNB/pdNB | MYCN: MNA | Gen. profile: SCA | 11q: 11qD | Risk group: high-risk | Gen. Instab.:High |
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IPP | Nuclei | Dens. | – | 0.005↑ | 0.007↑ | 0.001↑ | – | – | 0.001↑ | 0.003↑ |
%SA | 0.004↑ | – | – | – | 0.018↓ | – | – | – |
Inter.VN | %SA | – | – | – | – | – | – | – | – |
Terr.VN | %SA | – | 0.010↑ | 0.001↑* | 0.024↑ | 0.001↑ | 0.035↑ | 0.008↑ | 0.000↑ |
Densito | VN ratio of pixels | Weak | – | – | – | – | – | – | – | – |
Mod. | – | – | – | – | – | – | – | – |
Strong | – | 0.037↑ | 0.010↑* | 0.011↑ | 0.002↑ | 0.021↑ | 0.004↑ | 0.010 ↑ |
H-score | – | – | 0.019↑ | 0.040↑ | 0.011↑ | – | 0.008↑ | 0.001↑ |
- Only morphometric variables for vitronectin (VN) expression and nuclei having a statistically significant relationship with pre-treatment risk stratification factors are shown (p-value< 0.05). IPP: Image Pro-Plus; Densito: DensitoQuant; Dens. Density (number of objects/mm2); %SA: percentage of stained area; Inter. VN: Interterritorial VN; Terr.VN: Territorial VN; Mod.: moderate. M: metastatic; Hist.D: histopathologic differentiation; uNB: undifferentiated neuroblastoma; pdNB: poorly differentiated neuroblastoma; NOS was excluded from statistical analysis; Gen. Profile: genetic profile; SCA: segmental chromosomal aberration; MNA: MYCN amplified; 11qD: 11q deletion; Gen. Instab.: genetic instability. -: not statistically significant, ↑/↓: higher or lower median value for the poor-prognostic group(s). *There are statistically significant differences between pdNB and uNB, within Strong VN (p-value< 0.05) and %SA Territorial VN (p-value< 0.1) morphometric variables