Stochastic modelling of tyrosine kinase inhibitor rotation therapy in chronic myeloid leukaemia

BMC Cancer

Table 1 Global parameters

Parameter	Symbol	Value
Population size avg.	\(\hat {N}\)	250 000 cells [24]
Population size spring constant	κ	1.0
Mutation rate multiplier	μ	10⁻⁷ mutations/division^a
Unmodified growth rate	s ⁽⁰⁾	0.016 divisions/timestep^b [30]

^aThe number of mutations in a single residue per new cell where only one transversion can result in the specific amino-acid change. Mutations that result from transitions or more than one possible SNV have higher mutation rates, see Additional file 1: Section 5 and Table S1
^bCorresponds to approximately 0.3 – 0.4 divisions per day

ISSN: 1471-2407