Table 2 Baseline characteristics of 843 patients with LA-NPC
| Â | Low-ADC group | High-ADC group | P-value a |
|---|---|---|---|
Total | 473 | 370 | Â |
Age(years) | Â | Â | 0.732 |
Median(range) | 45(9–74) | 44 (12–72) |  |
< 44 | 236 (49.9%) | 189 (51.1%) |  |
≥44 | 237 (50.1%) | 181 (48.9%) |  |
Gender | Â | Â | 0.039 |
Male | 355 (75.1%) | 254 (68.6%) | Â |
Female | 118 (24.9%) | 116 (31.4%) | Â |
EBV-DNA | Â | Â | 0.960 |
Median(range) | 8.0 (0–5150.0) | 6.0 (0–2810.0) |  |
< 40.0 | 351 (74.2%) | 274 (74.1%) |  |
≥40.0 | 122 (25.8%) | 96 (25.9%) |  |
LDH (U/L) | Â | Â | 0.189 |
Median (range) | 183.2 (1.7–396.5) | 178.8 (108.0–753.0) |  |
< 245.0 | 431 (91.1%) | 327 (88.4%) |  |
≥245.0 | 42 (8.9%) | 43 (11.6%) |  |
WHO histologic type | Â | Â | 0.047 |
KSCC | 2 (0.4%) | 4 (1.1%) | Â |
DNKC | 7 (1.5%) | 14 (3.8%) | Â |
UNKC | 464 (98.1%) | 352 (95.1%) | Â |
Smoking | Â | Â | 0.596 |
No | 292 (61.7%) | 235 (63.5%) | Â |
Yes | 181 (38.3%) | 135 (36.5%) | Â |
Drinking | Â | Â | 0.593 |
No | 395 (83.5%) | 314 (84.9%) | Â |
Yes | 78 (16.5%) | 56 (15.1%) | Â |
Family history of cancer | Â | 0.966 | |
No | 356 (75.3%) | 278 (75.1%) | Â |
Yes | 117 (24.7%) | 92 (24.9%) | Â |
T classification b | Â | Â | 0.924 |
T1–2 | 65 (13.7%) | 50 (13.5%) |  |
T3–4 | 408 (86.3%) | 320 (86.5%) |  |
N classification b | Â | Â | 0.359 |
N0–1 | 263 (55.6%) | 194 (52.4%) |  |
N2–3 | 210 (44.4%) | 176 (47.6%) |  |
Overall stageb | Â | Â | 0.550 |
III | 269 (56.9%) | 218 (58.9%) | Â |
IVA | 204 (43.1%) | 152 (41.1%) | Â |
Treatment | Â | Â | 0.529 |
IC + CCRT | 188 (39.7%) | 155 (41.9%) |  |
CCRT | 285 (60.3%) | 215 (58.1%) | Â |