Association between TIMP-2 gene polymorphism and breast cancer in Han Chinese women

BMC Cancer

Table 3 Basic characteristics and allele frequencies of the six SNPs in the TIMP-2 gene

SNP	Gene	chromosome	Position	Allele	Minor allele frequency		HWE p value	OR (95%CI)	p
SNP	Gene	chromosome	Position	Allele	Case	Control	HWE p value	OR (95%CI)	p
rs2277698	TIMP-2	17q25.3	76,867,017	T/C	0.201	0.236	0.0651	0.81(0.67–0.99)	0.041^*
rs2009196	TIMP-2	17q25.3	76,870,581	C/G	0.392	0.426	0.3502	0.87(0.74–1.03)	0.099
rs7342880	TIMP-2	17q25.3	76,874,512	A/C	0.161	0.150	0.7433	1.09(0.87–1.37)	0.448
rs11654470	TIMP-2	17q25.3	76,877,331	C/T	0.23	0.273	0.0119^*	0.80(0.66–0.96)	0.019
rs2003241	TIMP-2	17q25.3	76,885,117	C/T	0.164	0.161	0.0196^*	1.02(0.82–1.28)	0.853
rs4789936	TIMP-2	17q25.3	76,897,974	T/C	0.299	0.307	0.6256	0.96(0.80–1.15)	0.658

SNP: single nucleotide polymorphism; OR: odds ratio; 95%CI: 95% confidence interval; HWE: Hardy-Weinberg equilibrium
*p < 0.05 indicates statistical significance

ISSN: 1471-2407