Table 1 Baseline characteristics
Characteristics | Total (N = 87) | TGF-β WT (N = 66) | TGF-β MT (N = 21) | P-Value | |
|---|---|---|---|---|---|
Age | Median (range) | 59 (31–75) | 61 (38–75) | 54 (31–74) | 0.020 |
Sex | Male | 50 (57.5%) | 36 (54.4%) | 14 (66.7%) | 0.33 |
Female | 37 (42.5%) | 30 (45.5%) | 7 (33.3%) | ||
Location | Proximal | 28 (32.2%) | 19 (28.8%) | 9 (42.9%) | 0.23 |
Distal | 59 (67.8%) | 47 (71.2%) | 12 (57.1%) | ||
Stage | II, high-risk | 14 (16.1%) | 8 (12.1%) | 6 (28.6%) | 0.074 |
III | 73 (83.9%) | 58 (87.9%) | 15 (71.4%) | ||
T stage | 1 | 0 (0.0%) | 0 (0.0%) | 0 (0.0%) | 0.41 |
2 | 1 (1.1%) | 1 (1.5%) | 0 (0.0%) | ||
3 | 62 (71.3%) | 49 (74.2%) | 13 (61.9%) | ||
4 | 24 (27.6%) | 16 (24.2%) | 8 (38.1%) | ||
N stage | 0 | 14 (16.1%) | 8 (12.1%) | 6 (28.6%) | 0.18 |
1 | 29 (33.3%) | 24 (36.4%) | 5 (23.8%) | ||
2 | 44 (50.6%) | 34 (51.5%) | 10 (47.6%) | ||
Histology | Non-MAC | 78 (89.7%) | 65 (98.5%) | 13 (61.9%) | < 0.001 |
MAC | 9 (10.3%) | 1 (1.5%) | 8 (38.1%) | ||
MSI | MSS/MSI-L | 83 (96.5%) | 65 (100.0%) | 18 (85.7%) | 0.013 |
MSI-H | 3 (3.5%) | 0 (0.0%) | 3 (14.3%) | ||
Time to recurrence | < 1 year | 19 (21.8%) | 11 (16.7%) | 8 (38.1%) | 0.038 |
≥1 year | 68 (78.2%) | 55 (83.3%) | 13 (61.9%) | ||
Curative resection after distant recurrence | Not done | 52 (59.8%) | 39 (59.1%) | 13 (61.9%) | 0.82 |
Done | 35 (40.2%) | 27 (40.9%) | 8 (38.1%) | ||