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Fig. 4 | BMC Cancer

Fig. 4

From: The histone methyltransferase WHSC1 is regulated by EZH2 and is important for ovarian clear cell carcinoma cell proliferation

Fig. 4

Correlation between WHSC1 and EZH2 expression in ovarian clear cell carcinoma. EZH2 knockdown was found to affect WHSC1 expression and its associated transcriptional activation marker, H3K36me2. a Correlation between the mRNA expression of WHSC1 and EZH2 indicating a positive correlation (correlation coefficient = 0.4175). b OVTOKO and OVISE cells were transfected with siRNAs (siNC and siEZH2#1 or #2). Knockdown of EZH2 by siEZH2 was confirmed by qPCR. c Expression of EZH2, H3K27me3, WHSC1, H3K36me2, and β-actin in OVISE cells with EZH2 knockdown, as assessed by western blotting. d After OVISE cells were transfected with siRNAs (siNC and siWHSC1#1/#2), western blotting was performed. Knockdown of WHSC1 did not affect the expression of EZH2

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BMC Cancer

ISSN: 1471-2407

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