Table 5 Univariate and multivariate logistic regression predictors of lobe non-specific mediastinal lymph node metastasis
Independents Variables | Univariate Predictors | Multivariate Predictors | ||
|---|---|---|---|---|
N Metastasis/N total | Odds Ratio (95% CI), P-value | B | Odds Ratio (95% CI), P-value | |
Age (years) | ||||
≤60 | 15/298 (5.0%) | Reference | ||
> 60 | 9/291 (3.1%) | 0.60 (0.26–1.40), 0.238 | ||
Sex | ||||
Female | 14/301 (4.7%) | Reference | ||
Male | 10/288 (3.5%) | 0.74 (0.32–1.69), 0.471 | ||
Maximum diameter of tumor | ||||
≤1.6 cm | 9/303 (3.0%) | Reference | ||
> 1.6 cm | 14/279 (5.0%) | 1.73 (0.74–4.05), 0.210 | ||
Position | 0.535 | |||
Right Upper Lobe | 5/181 (2.8%) | Reference | ||
Right Middle Lobe | 0/28 (0.0%) | 0.00 (0.00,) 0.998 | ||
Right Lower Lobe | 7/84 (8.3%) | 3.20 (0.99–10.40), 0.053 | ||
Left Upper Lobe | 4/135 (3.0%) | 1.08 (0.28–4.08), 0.916 | ||
Left Lower Lobe | 4/87 (4.6%) | 1.70 (0.44–6.48), 0.440 | ||
Ipsilateral Mixed lobes | 3/48 (6.3%) | 2.35 (0.54–10.19), 0.255 | ||
Bilateral Mixed lobes | 1/26 (3.8%) | 1.41 (0.16–12.55), 0.759 | ||
Pathological type | ||||
Adenocarcinoma | 17/440 (3.9%) | Reference | ||
Others | 7/147 (4.8%) | 1.24 (0.51–3.06), 0.635 | ||
Tumor differentiation | ||||
No | 3/153 (2.0%) | Reference | ||
Yes | 21/413 (5.1%) | 2.68 (0.79–9.11), 0.115* | ||
Pathological morphology | ||||
No | 8/209 (3.8%) | Reference | ||
Yes | 16/356 (4.5%) | 1.18 (0.50–2.81), 0.705 | ||
Pulmonary membrane invasion | ||||
No | 15/427 (3.5%) | Reference | ||
Yes | 4/57 (7.0%) | 2.07 (0.66–6.48), 0.210 | ||
Bronchial mucosa and cartilage invasion | ||||
No | 18/534 (3.4%) | Reference | ||
Yes | 6/54 (11.1%) | 3.58 (1.36–9.45), 0.010* | ||
Vascular invasion | ||||
No | 16/542 (3.0%) | Reference | ||
Yes | 8/44 (18.2%) | 7.31 (2.93–18.21), < 0.0001* | 1.59 | 4.89 (1.78–13.40), 0.002# |
Nerve invasion | ||||
No | 21/576 (3.6%) | Reference | ||
Yes | 3/12 (25.0%) | 8.81 (2.22–34.93), 0.002* | 1.55 | 4.73 (1.05–21.35), 0.043# |
CEA | ||||
≤2.21 ng/ml | 8/250 (3.2%) | Reference | ||
> 2.21 ng/ml | 14/253 (5.5%) | 1.77 (0.73–4.30), 0.206 | ||
Albumin | ||||
≤43.1 g/l | 12/287 (4..2%) | Reference | ||
> 43.1 g/l | 11/286 (3.8%) | 0.92 (0.40–2.11), 0.838 | ||