Table 2 Univariate and multivariate logistic regression predictors of interlobar lymph node metastasis
Independents Variables | Univariate Predictors | Multivariate Predictors | ||
|---|---|---|---|---|
N Metastasis/N total | Odds Ratio (95% CI), P-value | B | Odds Ratio (95% CI), P-value | |
Age (years) | ||||
≤60 | 19/216 (8.8%) | Reference | ||
> 60 | 10/202 (5.0%) | 0.54 (0.25–1.19), 0.540 | ||
Sex | ||||
Female | 10/207 (4.8%) | Reference | ||
Male | 19/211 (9.0%) | 1.95 (0.88–4.30), 0.098* | ||
Maximum diameter of tumor | ||||
≤1.6 cm | 8/205 (3.9%) | Reference | ||
> 1.6 cm | 21/209 (10.0%) | 2.75 (1.19–6.36), 0.018* | ||
Position | < 0.0001* | |||
Right Upper Lobe | 3/121 (2.5%) | Reference | ||
Right Middle Lobe | 0/22 (0.0%) | 0.00 (0.00-), 0.998 | ||
Right Lower Lobe | 16/61 (26.2%) | 13.99 (3.89–50.30), < 0.0001* | ||
Left Upper Lobe | 1/93 (1.1%) | 0.43 (0.04–4.18), 0.465 | ||
Left Lower Lobe | 6/67 (9.0%) | 3.87 (0.94–16.01), 0.062* | ||
Ipsilateral Mixed lobes | 1/35 (2.9%) | 1.16 (0.12–11.48), 0.901 | ||
Bilateral Mixed lobes | 2/17 (11.8%) | 5.24 (0.81–33.96), 0.082* | ||
Pathological type | ||||
Adenocarcinoma | 25/319 (7.8%) | Reference | ||
Others | 4/98 (4.1%) | 0.50 (0.17–1.48), 0.209 | ||
Tumor differentiation | ||||
No | 0/102 (0.0%) | Reference | ||
Yes | 29/302 (9.6%) | 171,607,233.80 (0.00-), 0.996 | ||
Pathological morphology | ||||
No | 8/140 (5.7%) | Reference | ||
Yes | 21/262 (8.0%) | 1.44 (0.62–3.34), 0.398 | ||
Pulmonary membrane invasion | ||||
No | 14/296 (4.7%) | Reference | ||
Yes | 5/40 (12.5%) | 2.88 (0.98–8.47), 0.055* | ||
Bronchial mucosa and cartilage invasion | ||||
No | 23/379 (6.1%) | Reference | ||
Yes | 6/39 (15.4%) | 2.81 (1.07–7.40), 0.036* | ||
Vascular invasion | ||||
No | 25/387 (6.5%) | Reference | ||
Yes | 4/30 (13.3%) | 2.23 (0.72–6.88), 0.164* | ||
Nerve invasion | ||||
No | 28/412 (6.8%) | Reference | ||
Yes | 1/6 (16.7%) | 2.74 (0.31–24.29), 0.365 | ||
CEA | ||||
≤2.21 ng/ml | 4/172 (2.3%) | Reference | ||
> 2.21 ng/ml | 18/182 (9.9%) | 4.61 (1.53–13.91), 0.007* | ||
Albumin | ||||
≤43.1 g/l | 22/195 (11.3%) | Reference | ||
> 43.1 g/l | 7/212 (3.3%) | 0.27 (0.11–0.64), 0.003* | ||