Skip to main content

Advertisement

Table 2 IHC expression of topoisomerase II a and correlation to the patients´ outcome

From: Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

  N OS [months] DFS [months]
expression   expression  
> 50% ≤50% p > 50% ≤50% p
all 430 n.a. 68.4 < 0.001 n.a. 48.4 0.010
age (years)
 < 65 211 n.a. 95.7 < 0.001 n.a. n.a. 0.111
 ≥ 65 215 110.1 53.6 0.188 n.a. n.a. 0.959
tumor site
 right colon 115 122.6 58.9 0.313 n.a. n.a. 0.197
 left colon + rectum 298 n.a. 68.4 < 0.001 n.a. n.a. 0.797
UICC
 I + II 217 n.a. n.a. 0.354 n.a. n.a. 0.207
 III 133 110.1 51.9 0.004 n.a. 32.4 0.020
 IV 76 30.2 17.6 0.027 16.6 13.6 0.223
histological grading
 I 9 n.a. n.a. n.a. n.a. n.a. 0.480
 II 339 n.a. 66.1 < 0.001 n.a. n.a. 0.283
 III 67 98.6. 28.8 0.207 n.a. n.a. 0.390
histology
 adeno carcinoma 364 n.a. 68.4 < 0.001 n.a. n.a. 0.259
 mucinous + signet-ring carcinoma 56 59.1 53.6 0.881 n.a. n.a. 0.923
resection margin
 R0 404 n.a. 58.9 0.009 n.a. n.a. 0.299
 R1 + R2 18 58.0 68.4 0.168 54.4 47.8 0.797
  1. All P values in bold, are regarded as statistically significant. Abbreviations: UICC Union internationale contre le cancer, n.a. not achieved