Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

Table 2 IHC expression of topoisomerase II a and correlation to the patients´ outcome

	N	OS [months]			DFS [months]
		expression			expression
		> 50%	≤50%	p	> 50%	≤50%	p
all	430	n.a.	68.4	< 0.001	n.a.	48.4	0.010
age (years)
< 65	211	n.a.	95.7	< 0.001	n.a.	n.a.	0.111
≥ 65	215	110.1	53.6	0.188	n.a.	n.a.	0.959
tumor site
right colon	115	122.6	58.9	0.313	n.a.	n.a.	0.197
left colon + rectum	298	n.a.	68.4	< 0.001	n.a.	n.a.	0.797
UICC
I + II	217	n.a.	n.a.	0.354	n.a.	n.a.	0.207
III	133	110.1	51.9	0.004	n.a.	32.4	0.020
IV	76	30.2	17.6	0.027	16.6	13.6	0.223
histological grading
I	9	n.a.	n.a.	n.a.	n.a.	n.a.	0.480
II	339	n.a.	66.1	< 0.001	n.a.	n.a.	0.283
III	67	98.6.	28.8	0.207	n.a.	n.a.	0.390
histology
adeno carcinoma	364	n.a.	68.4	< 0.001	n.a.	n.a.	0.259
mucinous + signet-ring carcinoma	56	59.1	53.6	0.881	n.a.	n.a.	0.923
resection margin
R0	404	n.a.	58.9	0.009	n.a.	n.a.	0.299
R1 + R2	18	58.0	68.4	0.168	54.4	47.8	0.797

All P values in bold, are regarded as statistically significant. Abbreviations: UICC Union internationale contre le cancer, n.a. not achieved