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Table 1 Patient demographics, clinical characteristics and univariate analysis (log rank test) influencing the overall survival (OS) disease free survival (DFS)

From: Prognostic relevance of topoisomerase II α and minichromosome maintenance protein 6 expression in colorectal cancer

  N (%) OS [months] P DFS [months] P
all 619 (100)     
age (years)
 < 65 303 (48.9) n.a. < 0.001 59.5 0.005
 ≥ 65 315 (50.9) 65.6   n.a.
 unknown 1 (0.2)    
sex
 male 312 (50.4) 119.1 0.961 n.a. 0.218
 female 307 (49.5) 104.3   n.a.
tumor site
 right colon 172 (27.8) 130.5 0.010 n.a. 0.299
 left colon + rectum 439 (70.1) 69.5   n.a.
 unknown 8 (1.3)    
UICC
 I + II 297 (48.0) 154.6 < 0.001 n.a. < 0.001
 III 199 (32.1) 87.0   49.8
 IV 117 (18.9) 22.1   13.7
 unknown 6 (1.0)    
histological grading
 I 10 (1.6) n.a. < 0.001 n.a. 0.007
 II 505 (81.6) 122.4   n.a.
 III 102 (16.5) 41.8   33.6
 unknown 2 (0.3)    
histology
 adeno carcinoma 525 (84.9) 122.6 < 0.001 n.a. 0.010
 mucinous carcinoma 74 (12.0) 68.3   40.7
 signet-ring cell carcinoma 7 (1.1) 12.3   9.4
 unknown 13 (2.1)    
resection margin
 R0 573 (92.6) 15.3 < 0.001 n.a. < 0.001
 R1 + R2 32 (5.2) 122.6   10.7
 unknown 14 (2.3)    
therapy
 sole surgical resection 229 (37.0)     
  + chemotherapy 136 (22.0)     
  + radiation 10 (1.6)     
  + chemoradiation 111 (17.9)     
  + unknown 133 (21.5)     
  1. All P values in bold, are regarded as statistically significant. Abbreviations: n.a. not achieved, UICC Union internationale contre le cancer