Table 4 ADRs Grade ≥ 3 Occurring in ≥1% of the Analysis Population by Age Subgroups
From: AVAiLABLE NIS – AVASTIN® in lung cancer treatment in routine oncology practice in Germany
Grade ≥ 3 ADRs | n (%) | ||||
|---|---|---|---|---|---|
Age groups [years] | < 65 (N = 567) | 65 to < 70 (N = 199) | 70 to < 75 (N = 134) | ≥ 75 (N = 72) | Analysis Population (N = 987) |
Any | 196 (34.6%) | 65 (32.7%) | 51 (38.1%) | 18 (25.0%) | 332 (33.6%) |
Leukopenia | 64 (11.3%) | 25 (12.6%) | 25 (18.7%) | 6 (8.3%) | 120 (12.2%) |
Neutropenia | 67 (11.8%) | 22 (11.1%) | 18 (13.4%) | 7 (9.7%) | 115 (11.7%) |
Thrombocytopenia | 47 (8.3%) | 14 (7.0%) | 13 (9.7%) | 3 (4.2%) | 78 (7.9%) |
Anemia | 34 (6.0%) | 4 (2.0%) | 9 (6.7%) | 2 (2.8%) | 50 (5.7%) |
Nausea | 20 (3.5%) | 1 (0.5%) | 7 (5.2%) | 3 (4.2%) | 31 (3.1%) |
Vomiting | 11 (1.9%) | 2 (1.0%) | 1 (0.7%) | 2 (2.8%) | 16 (1.6%) |
Diarrhea | 8 (1.4%) | 1 (0.5%) | 0 (0.0%) | 2 (2.8%) | 11 (1.1%) |
Pain | 11 (1.9%) | 2 (1.0%) | 4 (3.0%) | 1 (1.4%) | 18 (1.8%) |
Chest pain | 3 (0.5%) | 4 (2.0%) | 3 (2.2%) | 0 (0.0%) | 10 (1.0%) |
Pain in extremity | 6 (1.1%) | 3 (1.5%) | 4 (3.0%) | 1 (1.4%) | 14 (1.4%) |
Back pain | 6 (1.1%) | 3 (1.5%) | 2 (1.5%) | 1 (1.4%) | 12 (1.2%) |
Peripheral sensory neuropathy | 9 (1.6%) | 3 (1.5%) | 1 (0.7%) | 1 (1.4%) | 14 (1.4%) |
Hypertension | 8 (1.4%) | 4 (2.0%) | 1 (0.7%) | 3 (4.2%) | 16 (1.6%) |