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Fig. 7 | BMC Cancer

Fig. 7

From: Numb inhibits epithelial-mesenchymal transition via RBP-Jκ-dependent Notch1/PTEN/FAK signaling pathway in tongue cancer

Fig. 7

PTEN inhibition leads to increased expression of EMT-associated genes expression in the absence of RBP-Jk. a Western blot analyses showing the protein level of PTEN, FAK, p-FAK and EMT-related genes (N-cadherin, E-cadherin, Snail-1, MMP-9) in NC (sh-NC), RBP-Jκ-knockdown (RBP-Jκ shRNA), RBP-Jκ-knockdown (RBP-Jκ shRNA) plus VO-Ohpic trihydrat-treated SCC-9 and CAL-27 cells. GAPDH acts as internal control. b Gray level analysis of the protein level of PTEN, FAK, p-FAK and EMT-related genes (N-cadherin, E-cadherin, Snail-1, MMP-9) in NC (sh-NC), RBP-Jκ-knockdown (RBP-Jκ shRNA), RBP-Jκ-knockdown (RBP-Jκ shRNA) plus VO-Ohpic trihydrat-treated SCC-9 and CAL-27 cells. The mean ± SD represents the average levels from 3 replicates. *p < 0.05, **p < 0.01

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