Table 1 Expected toxicity and threshold limit values for the first 10 patients receiving standard mono-chemotherapy with docetaxel 75 mg/m2 each 21 days [7]
Toxicity | Grade of toxicity | Threshold limit value | ||
|---|---|---|---|---|
Any | ≥ 3 | Any | ≥ 3 | |
Anemia | 90% | 10.6% | – | > 3 of 10 |
Neutropenia | – | 76% | – | – |
Febrile Neutropenia | – | 11–25% | – | > 4 of 10 |
Thrombocytopenia | 8–14% | 1% | > 3 of 10 | > 1 of 10 |
AST | 5% | – | > 2 of 10 | > 1 of 10 |
ALT | 5% | – | > 2 of 10 | > 1 of 10 |
Bilirubin | 6–9% | 2% | > 2 of 10 | > 1 of 10 |
Creatinine | 5% | < 1 | > 1 of 10 | – |
Urea | 5% | < 1 | > 1 of 10 | – |
Constipation | 11.7% | 0.4% | > 3 of 10 | – |
Diarrhea | 36.4–39% | 1.8–5% | > 5 of 10 | > 2 of 10 |
Mucositis | 25.5% | 1.8% | > 4 of 10 | – |
Nausea | 36.4–39% | 3.6–4% | > 5 of 10 | > 2 of 10 |
Vomiting | 22–23.6% | 3–3.6% | > 4 of 10 | > 2 of 10 |
Asthenia | 54.5% | 18.2% | > 7 of 10 | > 4 of 10 |
Infection | 30.9% | 5.5% | > 4 of 10 | > 2 of 10 |