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Table 1 Expected toxicity and threshold limit values for the first 10 patients receiving standard mono-chemotherapy with docetaxel 75 mg/m2 each 21 days [7]

From: Impact of AferBio® on quality of life and chemotherapy toxicity in advanced lung cancer patients (AFERBIO study): protocol study for a phase II randomized controlled trial

Toxicity Grade of toxicity Threshold limit value
Any ≥ 3 Any ≥ 3
Anemia 90% 10.6% >  3 of 10
Neutropenia 76%
Febrile Neutropenia 11–25% >  4 of 10
Thrombocytopenia 8–14% 1% >  3 of 10 >  1 of 10
AST 5% >  2 of 10 >  1 of 10
ALT 5% >  2 of 10 >  1 of 10
Bilirubin 6–9% 2% >  2 of 10 >  1 of 10
Creatinine 5% <  1 >  1 of 10
Urea 5% <  1 >  1 of 10
Constipation 11.7% 0.4% >  3 of 10
Diarrhea 36.4–39% 1.8–5% >  5 of 10 >  2 of 10
Mucositis 25.5% 1.8% >  4 of 10
Nausea 36.4–39% 3.6–4% >  5 of 10 >  2 of 10
Vomiting 22–23.6% 3–3.6% >  4 of 10 >  2 of 10
Asthenia 54.5% 18.2% >  7 of 10 >  4 of 10
Infection 30.9% 5.5% >  4 of 10 >  2 of 10