Fig. 1
![Fig. 1](http://media.springernature.com/full/springer-static/image/art%3A10.1186%2Fs12885-019-5599-z/MediaObjects/12885_2019_5599_Fig1_HTML.png)
Schematic overview of the study design. In the non-randomized phase of the study, the same evaluations will be carried out, but all participants will receive the investigational product
Schematic overview of the study design. In the non-randomized phase of the study, the same evaluations will be carried out, but all participants will receive the investigational product