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Table 4 Association of the T cell activation status and mortality of breast cancer stratified by the CCND1 expression level

From: BRCA1 mRNA expression modifies the effect of T cell activation score on patient survival in breast cancer

Stratification   Death
Variable Variable HRa 95% CIb p-value
Low CCND1 T cell activation
 Exhaustion 1.00   
 Intermediate 0.67 0.41–1.10 0.113
 Activation 0.39 0.19–0.81 0.011
 p-trend   0.008  
 Age (per 5 years) 1.14 1.04–1.25 0.008
 Disease Stage 2.77 1.89–4.07 <.0001
Histological type
 Ductal 1.00   
 Lobular 0.61 0.34–1.12 0.109
 Mix 1.44 0.57–3.62 0.441
 Other 3.01 1.32–6.83 0.009
High CCND1 T cell activation
 Exhaustion 1.00   
 Intermediate 1.34 0.73–2.47 0.352
 Activation 0.91 0.33–2.52 0.854
 p-trend   0.822  
 Age (per 5 years) 1.26 1.15–1.38 <.0001
 Disease Stage 2.09 1.47–2.98 <.0001
Histological type
 Ductal 1.00   
 Lobular 0.69 0.35–1.36 0.281
 Mix 0.38 0.12–1.23 0.106
 Other 1.44 0.49–4.24 0.509
P value for the interaction between CCND1 level and T cell activation   0.135  
  1. aHR: adjusted hazard ratio, which was obtained from a multivariate Cox proportional hazards regression model
  2. bCI confidence interval