Stratification | Â | Death | ||
---|---|---|---|---|
Variable | Variable | HRa | 95% CIb | p-value |
Low CCND1 | T cell activation | |||
 Exhaustion | 1.00 |  |  | |
 Intermediate | 0.67 | 0.41–1.10 | 0.113 | |
 Activation | 0.39 | 0.19–0.81 | 0.011 | |
 p-trend |  | 0.008 |  | |
 Age (per 5 years) | 1.14 | 1.04–1.25 | 0.008 | |
 Disease Stage | 2.77 | 1.89–4.07 | <.0001 | |
Histological type | ||||
 Ductal | 1.00 |  |  | |
 Lobular | 0.61 | 0.34–1.12 | 0.109 | |
 Mix | 1.44 | 0.57–3.62 | 0.441 | |
 Other | 3.01 | 1.32–6.83 | 0.009 | |
High CCND1 | T cell activation | |||
 Exhaustion | 1.00 |  |  | |
 Intermediate | 1.34 | 0.73–2.47 | 0.352 | |
 Activation | 0.91 | 0.33–2.52 | 0.854 | |
 p-trend |  | 0.822 |  | |
 Age (per 5 years) | 1.26 | 1.15–1.38 | <.0001 | |
 Disease Stage | 2.09 | 1.47–2.98 | <.0001 | |
Histological type | ||||
 Ductal | 1.00 |  |  | |
 Lobular | 0.69 | 0.35–1.36 | 0.281 | |
 Mix | 0.38 | 0.12–1.23 | 0.106 | |
 Other | 1.44 | 0.49–4.24 | 0.509 | |
P value for the interaction between CCND1 level and T cell activation | Â | 0.135 | Â |