Table 2 Differential expressions of PD-1,PD-L1 and PD-L2 between the primary and metastatic tumors
|  | Primary(N = 83) | Metastasis (N = 163)a | ||||||
|---|---|---|---|---|---|---|---|---|
n(%) | Lung/lymph node n = 72 | Bone n = 41 | Brain n = 19 | Viscera n = 16 | Adrenal gland n = 6 | Others n = 20 | Total n(%) | |
PD-1 | ||||||||
 Negative | 57(68.7) | 25(34.7) | 28(68.3) | 17(89.5) | 14(87.5) | 5(83.3) | 12(60.0) | 101(58.0) |
 Positive | 26(31.3) | 47(65.3) | 13(31.7) | 2(10.5) | 2(12.5) | 1(16.7) | 8(40.0) | 73(42.0) |
 P value |  | < 0.001 | 0.77 | < 0.001 | 0.01 | 0.21 | 0.85 | 0.11 |
PD-L1 | ||||||||
 Negative | 63(75.9) | 45(62.5) | 36(87.8) | 13(68.4) | 11(68.8) | 5(83.3) | 14(70.0) | 124(71.3) |
 Positive | 20(24.1) | 27(37.5) | 5(12.2) | 6(31.6) | 5(31.3) | 1(16.7) | 6(30.0) | 50(28.7) |
 P value |  | 0.03 | 0.01 | 0.77 |  | 0.51 | 0.89 | 0.44 |
PD-L2 | ||||||||
 Negative | 69(83.1) | 55(76.4) | 31(75.6) | 17(89.5) | 10(62.5) | 3(50.0) | 17(85.0) | 133(76.4) |
 Positive | 14(16.9) | 17(23.6) | 10(24.4) | 2(10.5) | 6(37.5) | 3(50.0) | 3(15.0) | 41(23.6) |
 P value |  | 0.99 | 0.21 | 0.16 | 0.17 | 0.12 | 0.34 | 0.22 |