A preliminary investigation of circulating extracellular vesicles and biomarker discovery associated with treatment response in head and neck squamous cell carcinoma

Table 1 Clinical and pathologic characteristics of the patients included in the study. All p values were based on 2-tailed chi square test

Variables		N of cases (%)	CR n (%)	NR n (%)	X² (p value)
Gender	Male	12 (100.0)	6 (50.0)	6 (50.0)	1.0
Gender	Female	0 (0)	0 (0)	0 (0)	1.0
Age	<=60 years	10 (83.3)	5 (41.7)	5 (41.7)	1.0
Age	> 60 years	2 (16.7)	1 (8.3)	1 (8.3)	1.0
Tobacco Consumption	yes	11 (91.7)	6 (50.0)	5 (41.7)	0.2963
Tobacco Consumption	no	1 (8.3)	0 (0)	1 (8.3)	0.2963
Tumor site	Oral Cavity	2 (16.7)	0 (0.0)	2 (16.7)	0.6283
	Oropharynx	8 (66.7)	4 (33.3)	4 (33.3)
	Larynx	2 (16.7)	2 (16.7)	0 (0.0)
HPV status^a	p16+	1 (8.33)	1 (8.3)	0 (0.0)	0.2963
HPV status^a	p16-	11 (81.7)	5 (41.7)	6 (50.0)	0.2963
Tumor stage	III	3 (25.0)	3 (25.0)	0 (0)	0.1824
Tumor stage	IV	9 (75.0)	3 (25.0)	6 (50.0)	0.1824

Abbreviations: CR complete response to chemoradiotherapy, NR incomplete response to chemoradiotherapy
^aHPV status was determined retrospectively using archival tumor specimens

ISSN: 1471-2407