BMC Cancer

Table 3 Performance of the gene expression signature

From: A specific gene expression signature for visceral organ metastasis in breast cancer

Gene expression signature			Training data set			Independent data set
		Signature	Visceral metastasis
		Signature	yes	no	p	yes	no	p
14-gene expression signature^a	All	present	68	4	2.13e-08	170	101	9.68e-06*
	All	absent	44	35	2.13e-08	39	66	9.68e-06*
	ER-positive	present	51	3	3.2e-08	80	80	4.50e-02**
	ER-positive	absent	25	29	3.2e-08	31	54	4.50e-02**
	ER-negative	present	22	2	0.211	79	25	4.37e-01***
	ER-negative	absent	14	5	0.211	16	8	4.37e-01***

Abbreviations: ER, estrogen receptor
^aThe 14-gene expression signature developed in this study
*sensitivity: 81.3%, specificity: 39.5%
**sensitivity: 72.1%, specificity: 40.3%
***sensitivity: 83.2%, specificity: 24.2%

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ISSN: 1471-2407

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