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Table 3 Performance of the gene expression signature

From: A specific gene expression signature for visceral organ metastasis in breast cancer

Gene expression signature Training data set Independent data set
   Signature Visceral metastasis
yes no p yes no p
14-gene expression signaturea All present 68 4 2.13e-08 170 101 9.68e-06*
absent 44 35 39 66
ER-positive present 51 3 3.2e-08 80 80 4.50e-02**
absent 25 29 31 54
ER-negative present 22 2 0.211 79 25 4.37e-01***
absent 14 5 16 8
  1. Abbreviations: ER, estrogen receptor
  2. aThe 14-gene expression signature developed in this study
  3. *sensitivity: 81.3%, specificity: 39.5%
  4. **sensitivity: 72.1%, specificity: 40.3%
  5. ***sensitivity: 83.2%, specificity: 24.2%