Differential proteomic comparison of breast cancer secretome using a quantitative paired analysis workflow

BMC Cancer

Table 4 List of 14 non-redundant proteins by maximum parsimony criteria found as differentially abundant after paired comparison of NAF samples from ER positive breast cancer patients

Accession number	Stouffer’s p-value^a	# of peptides^b	Sequence coverage^c	Protein description^d
P02768	1.22E-08	352	87%	Serum albumin
P01023	6.57E-06	113	59%	Alpha-2-macroglobulin
Q6YHK3	0.000399054	32	24%	CD109 antigen
P02787	0.000477172	126	76%	Serotransferrin
P01871	0.002477974	58	70%	Immunoglobulin heavy constant mu
P04217	0.00467967	22	48%	Alpha-1B-glycoprotein
P15086	0.008832761	37	66%	Carboxypeptidase B
P02763	0.012584332	15	33%	Alpha-1-acid glycoprotein 1
P06312	0.014788016	9	36%	Immunoglobulin kappa variable 4–1
P02794	0.02097625	14	40%	Ferritin heavy chain
P00450	0.02154448	94	58%	Ceruloplasmin
Q08380	0.022181763	59	51%	Galectin-3-binding protein
P05109	0.024051217	9	63%	Protein S100-A8
P02788	0.997617412	414	88%	Lactotransferrin

^aThe Stouffer’s p-value obtained from the independent peptide p-values mapping to the respective protein
^bThe # of peptides refers to the number of peptides considered for the calculation of the Stouffer’s p-value
^cThe Sequence coverage was calculated considering all peptides mapping to the respective protein
^dThe Protein description reflects the UniProt description

ISSN: 1471-2407