Table 6 Predictive factors for grade 2 to 5 toxicities
Variable | Rate of G2–5 toxicities | Chi Square | Binary logistic regression | p-value | Binary logistic regression | p-value |
|---|---|---|---|---|---|---|
Gender | ||||||
Male (n = 35) | 25.7% | p = 0.2 | NI | NI | ||
Female (n = 11) | 9.1% | |||||
Age | ||||||
≥ 66 years (n= 23) | 30.4% | p = 0.15 | NI | NI | ||
< 66 years (n = 23) | 13% | |||||
Period between irradiations | ||||||
> 24 months (n = 20) | 20% | p = 0.7 | NI | NI | ||
≤ 24 months (n = 25) | 24% | |||||
Missing value (n = 1) | ||||||
> 12 months (n = 36) | 16.7% | p = 0.07 | NI | NI | ||
≤ 12 months (n = 9) | 44.4% | |||||
Missing value (n = 1) | ||||||
Dose of first irradiation | ||||||
BED < 76 Gy (n = 18) | 22.2% | p = 0.9 | NI | NI | ||
BED ≥76 Gy (n = 28) | 21.4% | |||||
Dose of reirradiation | ||||||
BED ≤130 Gy (n = 18) | 27.8% | p = 0.4 | NI | NI | ||
BED > 130 Gy (n = 28) | 17.9% | |||||
Tumor size | ||||||
≥ 33 mm (n = 21) | 38.1% | p = 0.02 | 1 | p = 0.10 | 1 | p = 0.09 |
< 33 mm (n = 22) | 9.1% | OR = 0.22 | OR = 0.21 | |||
Missing value (n = 3) | [0.04–1.36] | [0.04–1.2] | ||||
GTV Volume | ||||||
≥ 13 mL (n = 22) | 36.4% | p = 0.03 | NI | |||
< 13 mL (n = 22) | 9.1% | NI | ||||
Missing value (n = 2) | ||||||
SABR duration | ||||||
≥ 6 days (n = 25) | 36% | p = 0.8 | NI | NI | ||
< 6 days (n = 21) | 38.1% | |||||
Number of fractions | ||||||
> 3 (n = 30) | 26.7% | p = 0.2 | NI | NI | ||
≤ 3 (n = 16) | 12.5% | |||||
Dose per fraction | ||||||
> 12 (n = 23) | 13% | p = 0.15 | NI | NI | ||
≤ 12 (n = 16) | 30.4% | |||||
Performans Status - ECOG * | ||||||
0 (n = 27) | 22.2% | p = 0.3 | NI | NI | ||
1 (n = 11) | 9.1% | |||||
Missing value (n = 8) | ||||||
Location of relapse | ||||||
Central (n = 24) | 37.5% | p = 0.007 | 1 | p = 0.07 | 1 | p = 0.03 |
Peripheral (n = 22) | 4.5% | OR = 0.12 [0.01–1.17] | OR = 6.4 [1.1–37.7] | |||
In-field relapse and central tumors | ||||||
No (n = 27) | 7.4% | p = 0.005 | NI | NI | ||
Yes (n = 19) | 42.1% | |||||
Primary stage (at first irradiation) | ||||||
IIIA (n = 21) | 28.6% | p = 0.3 | NI | NI | ||
IIIB (n = 25) | 16% | |||||
In-field relapse | ||||||
Yes (n = 29) | 31% | 1 | p = 0.3 | |||
No (n = 17) | 5.9% | p = 0.04 | OR = 0.33 [0.03–3.49] | |||