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Table 6 Predictive factors for grade 2 to 5 toxicities

From: Long term efficacy and toxicity after stereotactic ablative reirradiation in locally relapsed stage III non-small cell lung cancer

Variable Rate of G2–5 toxicities Chi Square Binary logistic regression p-value Binary logistic regression p-value
Gender
 Male (n = 35) 25.7% p = 0.2 NI   NI  
 Female (n = 11) 9.1%      
Age
  ≥ 66 years (n= 23) 30.4% p = 0.15 NI   NI  
  < 66 years (n = 23) 13%      
Period between irradiations
  > 24 months (n = 20) 20% p = 0.7 NI   NI  
  ≤ 24 months (n = 25) 24%      
 Missing value (n = 1)       
  > 12 months (n = 36) 16.7% p = 0.07 NI   NI  
  ≤ 12 months (n = 9) 44.4%      
 Missing value (n = 1)       
Dose of first irradiation
 BED < 76 Gy (n = 18) 22.2% p = 0.9 NI   NI  
 BED ≥76 Gy (n = 28) 21.4%      
Dose of reirradiation
 BED ≤130 Gy (n = 18) 27.8% p = 0.4 NI   NI  
 BED > 130 Gy (n = 28) 17.9%      
Tumor size
  ≥ 33 mm (n = 21) 38.1% p = 0.02 1 p = 0.10 1 p = 0.09
  < 33 mm (n = 22) 9.1%   OR = 0.22   OR = 0.21  
 Missing value (n = 3)    [0.04–1.36]   [0.04–1.2]  
GTV Volume
  ≥ 13 mL (n = 22) 36.4% p = 0.03    NI  
  < 13 mL (n = 22) 9.1%   NI    
 Missing value (n = 2)       
SABR duration
  ≥ 6 days (n = 25) 36% p = 0.8 NI   NI  
  < 6 days (n = 21) 38.1%      
Number of fractions
  > 3 (n = 30) 26.7% p = 0.2 NI   NI  
  ≤ 3 (n = 16) 12.5%      
Dose per fraction
  > 12 (n = 23) 13% p = 0.15 NI   NI  
  ≤ 12 (n = 16) 30.4%      
Performans Status - ECOG *
 0 (n = 27) 22.2% p = 0.3 NI   NI  
 1 (n = 11) 9.1%      
 Missing value (n = 8)       
Location of relapse
 Central (n = 24) 37.5% p = 0.007 1 p = 0.07 1 p = 0.03
 Peripheral (n = 22) 4.5%   OR = 0.12 [0.01–1.17]   OR = 6.4 [1.1–37.7]  
In-field relapse and central tumors
 No (n = 27) 7.4% p = 0.005 NI   NI  
 Yes (n = 19) 42.1%      
Primary stage (at first irradiation)
 IIIA (n = 21) 28.6% p = 0.3 NI   NI  
 IIIB (n = 25) 16%      
In-field relapse
 Yes (n = 29) 31%   1 p = 0.3   
 No (n = 17) 5.9% p = 0.04 OR = 0.33 [0.03–3.49]