Table 1 The relationship between m6A enzyme mRNA expression and clinicopathological parameters with breast cancer. (Data from bc-GenExMiner v4.0)
From: Changes of N6-methyladenosine modulators promote breast cancer progression
Parameter | Status | METTL3 | METTL14 | WTAP | KIAA1429 | FTO | ALKBH5 | ||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
No. | mRNA | No. | mRNA | No. | mRNA | No. | mRNA | No. | mRNA | No. | mRNA | ||
Age | ≤51 | 1302 | 1 | 810 | 1 | 1303 | 1 | 548 | 1 | 1192 | 1 | 766 | 1 |
> 51 | 2051 | Nc | 1673 | Nc | 2051 | Nc | 959 | Nc | 1896 | Nc | 1546 | Up** | |
ER (IHC) | – | 1488 | 1 | 949 | 1 | 1376 | 1 | 453 | 1 | 1383 | 1 | 892 | 1 |
+ | 3810 | Up*** | 2374 | Up*** | 3588 | Down*** | 1282 | Up*** | 3650 | Up*** | 2261 | Up** | |
PR (IHC) | – | 871 | 1 | 560 | 1 | 729 | 1 | 270 | 1 | 871 | 1 | 560 | 1 |
+ | 1365 | Up*** | 935 | Up*** | 1175 | Down*** | 504 | Up*** | 1365 | Up*** | 935 | Up* | |
HER2 (IHC) | – | 1286 | 1 | 548 | 1 | 1286 | 1 | 405 | 1 | 1286 | 1 | 548 | 1 |
+ | 175 | Nc | 134 | Nc | 175 | Nc | 122 | Down* | 175 | Down** | 134 | Nc | |
TNBC | + | 356 | 1 | 179 | 1 | 356 | 1 | 116 | 1 | 356 | 1 | 179 | 1 |
– | 3968 | Up*** | 2494 | Up*** | 3726 | Down*** | 1366 | Up** | 3808 | Up* | 2381 | Nc | |
Nodal | – | 2375 | 1 | 1251 | 1 | 2376 | 1 | 698 | 1 | 2230 | 1 | 1251 | 1 |
+ | 1432 | Nc | 1064 | Up* | 1432 | Nc | 571 | Nc | 1312 | Nc | 1064 | Nc | |