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Table 1 Unique interactions from the top 50 scoring edges based on the smoothed mutational score, pooled across all patients

From: Protein interaction disruption in cancer

Gene 1 Gene 2 Prop. score Top rank References
STEAP1B STEAP1 0.300938 1 [4951, 57]
TAS1R2 TAS1R3 0.277285 2  
SCGB3A2 MARCO 0.244833 3 [52, 53]
CYP2A7 CYP2A13 0.244117 4 [47, 48]
CNGB1 ABCA4 0.242088 6 [58, 59]
PLXND1 SEMA3E 0.229689 12 [60]
GSTA5 GSTA2 0.211860 14 [61]
UGT2B15 UGT2A3 0.210076 15 [62, 63]
CX3CR1 CX3CL1 0.206455 16 [6466]
GFRA3 ARTN 0.204744 21 [6770]
GRID2 GRID2IP 0.202544 33 [71]
PLXNC1 SEMA7A 0.199880 34 [60, 72]
HAS2 HAS3 0.199088 35 [73, 74]
OBP2B OBP2A 0.197566 37 [75, 76]
CD180 LY86 0.195079 39 [77, 78]
ZNF221 ZNF225 0.193870 42 [79, 80]
PSPN GFRA4 0.192038 45 [81, 82]
LIPE FABP9 0.190075 47 [83, 84]
KCNC1 KCNC2 0.189430 48 [85, 86]
  1. References refer to prior information about the involvement of these proteins in breast or other types of cancers. See Additional file 1: Table S2 for complete details and more information
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