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Table 1 Percentages of the different immune cells of viable peripheral blood mononuclear cells in patients with classical Hodgkin lymphoma (cHL), high-grade B-cell lymphoma (HGBCL) and healthy blood donors. Mann-Whitney U test was performed comparing the different groups and p-values refer to all lymphoma patients vs healthy blood donors

From: Altered profile of immune regulatory cells in the peripheral blood of lymphoma patients

Cell type CHL HGBCL Blood donor p-value
  Mean/Median (range) std Mean/Median (range) std Mean/Median (range) std  
T-cells CD3+ 41.8/45.1 (3.9–65) 15.6 40.2/37.9 (14.8–61.4) 11.8 50.7/53.4 (36–64.1) 9.5 0.03
T-regulatory cells
CD3+/CD4+/CD25+/CD127low
4.4/3.8 (0.4–10.9) 2.4 5.3/4 (1.2–30.5) 5.9 4.1/3.4 (0.4–8) 2.5 0.6
CD4+/CD8+ ratio 2/1.6 (0.18–4.9) 1.4 2.9/1.9 (0.5–16.2) 3.4 2/1.6 (0.53–7.4) 0.7
Monocytes CD33++/CD14+/HLA-DR+ 20.9/20.6 (4–47) 11.7 25.2/22.8 (9.3–66) 11.8 18.7/18.5 (3.5–33) 8.8 0.2
NK cells CD7+/CD3CD56+/CD16+ 6.5/4.4 (0.29–27.6) 6.1 6.4/5.2 (0.2–24.8) 5.5 9/8.9 (0.04–19.4) 4.9 0.1
NK regulatory cells CD7+/CD3/CD56++/CD16dim/− 0.28/0.21 (0.007–0.89) 0.26 0.31/0.25 (0.003–0.92) 0.25 0.54/0.44 (0.02–1.6) 0.36 0.003
Monocytic MDSC
CD11b+/HLA-DR/CD33+/CD14+
1.1/0.53 (0.043–3.7) 1.1 0.61/0.41 (0.024–2.2) 0.57 0.49/0.31 (0.015–2.7) 0.66 0.07
Granulocytic MDSC
CD11b+/HLA-DRdim/CD33dim/CD14-
12.7/8.1 (0.6–83.8) 18.3 5.7/4.2 (0.4–19.3) 4.96 3.8/1.1 (0.18–17.4) 5.2 0.003
  1. Abbreviations: CHL classic Hodgkin lymphoma, HGBCL high grade B-cell lymphoma, std. standard deviation, MDSC myeloid derived suppressor cells