Table 2 Mean survival (months) estimates from studies of patients with mixed histologies

REVEL

Ram + Doc (628)

Plac + Doc (625)

 RMS [95% CI]

to 19 mos

11.00 [10.47–11.52]

10.01 [9.48–10.55]

0.99 [0.24–1.73]

 Mean total OS

R_mSext

15.02

14.31

0.71

 Mean total OS

Weibull [95% CI]

14.87 [13.40–16.57]

12.99 [11.71–14.46]

1.88 [−0.22–3.98]

 Mean total OS

Weibull formula

14.87

12.98

1.89

LUME LUNG-1

Nin + Doc (655)

Plac + Doc (659)

 RMS [95% CI]

to 19 mos

10.85 [10.35–11.36]

10.38 [9.88–10.87]

0.48 [−0.23–1.18]

 Mean total OS

R_mSext

14.38

13.57

0.82

 Mean total OS

Weibull [95% CI]

14.08 [12.97–15.31]

13.21 [12.17–14.35]

0.87 [− 0.73–2.47]

 Mean total OS

Weibull formula

14.08

13.20

0.88

POPLAR

Atezolizumab (144)

Docetaxel (143)

 RMS [95% CI]

to 19 mos

11.84 [10.71–12.97]

10.39 [9.33–11.46]

1.45 [−0.11–3.00]

 Mean total OS

R_mSext

20.76

13.00

7.76

 Mean total OS

Weibull [95% CI]

17.89 [13.69–24.31]

12.15 [10.02–15.05]

5.74 [−0.135–11.61]

 Mean total OS

Weibull formula

17.93

12.15

5.78

OAK

Atezolizumab (425)

Docetaxel (425)

 RMS [95% CI]

to 19 mos

12.31 [11.65–12.96]

10.68 [10.03–11.33]

1.62 [0.70–2.55]

 Mean total OS

R_mSext

20.76

12.24

8.52

 Mean total OS

Weibull [95% CI]

18.93 [16.54–21.81]

13.59 [12.11–15.32]

5.34 [2.25–8.43]

 Mean total OS

Weibull formula

18.98

13.34

5.64

KEYNOTE-010

Pembrolizumab (344)

Docetaxel (343)

 RMS [95% CI]

to 19 mos

11.40 [10.62–12.19]

9.82 [9.05–10.59]

1.58 [0.48–2.68]

 Mean total OS

R_mSext

20.64

12.74

7.89

 Mean total OS

Weibull [95% CI]

16.14 [13.51–19.68]

11.10 [9.68–12.88]

5.04 [1.57–8.52]

 Mean total OS

Weibull formula

16.43

10.42

6.01

TAILOR

Erlotinib (109)

Docetaxel (110)

 RMS [95% CI]

to 19 mos

7.66 [6.15–8.81]

9.30 [8.02–10.57]

−1.64 [−3.36–0.08]

 Mean total OS

R_mSext

8.90

11.16

−2.26

 Mean total OS

Weibull [95% CI]

8.67 [6.99–10.86]

11.11 [8.80–14.25]

− 2.44 [−5.78–0.90]

 Mean total OS

Weibull formula

8.67

11.10

−2.43

HORG

Erlotinib (166)

Pemetrexed (166)

 RMS [95% CI]

to 19 mos

10.18 [9.10–11.26]

9.85 [8.73–10.97]

0.33 [− 1.23–1.88]

 Mean total OS

R_mSext

15.33

14.42

0.91

 Mean total OS

Weibull [95% CI]

15.02 [11.94–18.94]

13.86 [11.21–17.35]

1.16 [−3.5–5.82]

 Mean total OS

Weibull formula

15.12

13.86

1.25

Hanna

Pemetrexed (283)

Docetaxel (288)

 RMS [95% CI]

to 19 mos

8.80 [8.10–9.50]

8.70 [7.96–9.44]

0.10 [−0.92–1.12]

 Mean total OS

R_mSext

9.64

8.83

0.81

 Mean total OS

Weibull [95% CI]

9.34 [8.30–10.57]

9.35 [8.20–10.74]

−0.01 [−1.71–1.69]

 Mean total OS

Weibull formula

9.34

9.34

−0.01