Fig. 4
Patterns of differential expression (sarcoma vs. normal) of feline orthologs of human oncogenes and tumor suppressor genes (TSGs) significantly differ from those of feline genes whose orthologs are not oncogenes or TSGs. a Estimated density distributions of log2(sarcoma/skin) values for 1542 feline genes that are differentially expressed in tissues and that are orthologs of human TSGs, oncogenes, or genes that are neither TSGs nor oncogenes (“neither”). b Estimated density distributions of log2(sarcoma cells / fibroblast) values for 3049 feline genes that are differentially expressed in cultured cells and that are orthologs of human TSGs, oncogenes, or genes that are neither TSGs nor oncogenes (“neither”).c Proportions of genes that are up- or down-regulated in sarcoma vs. normal skin tissue, for 1542 feline genes classified by their human orthologs’ annotations (“TSG”, “oncogene”, or “neither”) show a clear trend of increasing odds of upregulation, between TSG, neither, and oncogene groups. d Proportions of genes that are up- or down-regulated in sarcoma-derived cells vs. skin-derived fibroblasts, for 3049 feline genes classified by their human orthologs’ annotations (“TSG”, “oncogene”, or “neither”) show a clear trend of increasing odds of upregulation, between TSG, neither, and oncogene groups