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Table 4 Survival outcomes according to the sequential use of risk scores during repeated TACE rounds

From: Feasibility of dynamic risk assessment for patients with repeated trans-arterial chemoembolization for hepatocellular carcinoma

Risk scores

Median survival (95% CI)

Survival rate

Cox regression

1-year

3-years

5-years

HR (95% CI)

P value*

mHAP-II (n = 619)

 A-B at the first TACE (n = 283)

 No second TACE (n = 55)

 A-B at the second TACE (n = 185)

40.6 (36.6–44.6)

89.6%

58.6%

35.5%

1

 C-D at the second TACE (n = 43)

19.6 (16.6–22.6)

66.8%

25.4%

16.4%

2.15 (1.48–3.12)

<0.001

 C-D at the first TACE (n = 336)

21.5 (18.5–24.5)

65.7%

31.3%

16.8%

2.31 (1.85–2.87)

<0.001

mHAP (n = 619)

 A-B at the first TACE (n = 519)

 No second TACE (n = 82)

 A-B at the second TACE (n = 412)

31.2 (27.5–34.9)

81.2%

44.6%

26.2%

1

 

 C-D at the second TACE (n = 25)

16.9 (2.9–30.9)

56.0%

16.0%

8.0%

2.28 (1.49–3.48)

<0.001

 C-D at the first TACE (n = 100)

10.2 (8.3–12.1)

40.2%

15.5%

9.3%

2.91 (2.29–3.69)

<0.001

HAP (n = 619)

 A-B at the first TACE (n = 394)

 No second TACE (n = 71)

 A-B at the second TACE (n = 278)

35.8 (31.3–40.3)

84.6%

49.6%

30.0%

1

 

 C-D at the second TACE (n = 45)

21.0 (15.0–27.0)

70.6%

23.9%

12.1%

1.84 (1.30–2.62)

0.001

 C-D at the first TACE (n = 225)

48.6 (14.2–23.0)

60.2%

27.4%

15.7%

2.17 (1.77–2.66)

<0.001

  1. P value* indicate the comparison with A-B of risk scores at the first TACE
  2. TACE trans-arterial chemoembolization, CI confidence interval, HR hazard ratio, mHAP modified hepatoma arterial-embolization prognostic