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Table 3 Association between PD-L1 expression and clinicopathological features

From: The prognostic and clinicopathological significance of PD-L1 expression in patients with diffuse large B-cell lymphoma: a meta-analysis

Clinicopathological parameters No. of studies No. of patients Model Pooled OR 95%CI P Heterogeneity
I 2 P
Age ≤60 vs. >60 12 1582 Fixed 0.887 0.675–1.166 0.390 0 0.744
Sex female vs. male 11 1457 Fixed 1.068 0.819–1.392 0.626 9.50% 0.353
Pathology GCB vs. non-GCB 10 1413 Fixed 2.891 2.087–4.003 0 4.00% 0.404
Stage I-II vs. III-IV 9 1336 Fixed 1.209 0.915–1.599 0.182 26.40% 0.209
IPI 3–5 vs. 0–2 7 993 Fixed 1.552 1.111–2.169 0.010 12.40% 0.335
ECOG ≤1 vs. >1 7 1048 Random 1.006 0.445–2.274 0.988 64.40% 0.010
B symptom no vs. yes 9 1345 Fixed 1.495 1.109–2.015 0.008 48.30% 0.051
CR no vs. yes 5 632 Random 1.109 0.552–2.230 0.771 54.80% 0.065
LDH normal vs. elevated 7 827 Fixed 1.341 0.939–1.915 0.107 25.50% 0.234
EB no vs. yes 5 860 Random 2.180 0.485–9.799 0.309 72.20% 0.006
BCL-2 negative vs. positive 4 357 Fixed 1.510 0.857–2.661 0.154 0 0.776
BCL-6 negative vs. positive 3 232 Fixed 2.414 1.263–4.612 0.008 24.50% 0.266
CD10 negative vs. positive 3 233 Fixed 4.367 1.626–11.729 0.003 36.70% 0.206
MUM1 negative vs. positive 3 233 Fixed 3.365 1.578–7.175 0.002 22.80% 0.274
MYC negative vs. positive 3 244 Fixed 1.252 0.647–2.420 0.504 0 0.627
ki-67% low vs. high 4 397 Fixed 0.876 0.535–1.433 0.598 0 0.987
  1. IPI international prognostic index; ECOG Eastern Cooperative Oncology Group; GCB germinal center B-cell-like; OR odd ratio; LDH Lactic dehydrogenase; CR complete remission