The prognostic and clinicopathological significance of PD-L1 expression in patients with diffuse large B-cell lymphoma: a meta-analysis

Table 3 Association between PD-L1 expression and clinicopathological features

Clinicopathological parameters		No. of studies	No. of patients	Model	Pooled OR	95%CI	P	Heterogeneity
Clinicopathological parameters		No. of studies	No. of patients	Model	Pooled OR	95%CI	P	I ²	P
Age	≤60 vs. >60	12	1582	Fixed	0.887	0.675–1.166	0.390	0	0.744
Sex	female vs. male	11	1457	Fixed	1.068	0.819–1.392	0.626	9.50%	0.353
Pathology	GCB vs. non-GCB	10	1413	Fixed	2.891	2.087–4.003	0	4.00%	0.404
Stage	I-II vs. III-IV	9	1336	Fixed	1.209	0.915–1.599	0.182	26.40%	0.209
IPI	3–5 vs. 0–2	7	993	Fixed	1.552	1.111–2.169	0.010	12.40%	0.335
ECOG	≤1 vs. >1	7	1048	Random	1.006	0.445–2.274	0.988	64.40%	0.010
B symptom	no vs. yes	9	1345	Fixed	1.495	1.109–2.015	0.008	48.30%	0.051
CR	no vs. yes	5	632	Random	1.109	0.552–2.230	0.771	54.80%	0.065
LDH	normal vs. elevated	7	827	Fixed	1.341	0.939–1.915	0.107	25.50%	0.234
EB	no vs. yes	5	860	Random	2.180	0.485–9.799	0.309	72.20%	0.006
BCL-2	negative vs. positive	4	357	Fixed	1.510	0.857–2.661	0.154	0	0.776
BCL-6	negative vs. positive	3	232	Fixed	2.414	1.263–4.612	0.008	24.50%	0.266
CD10	negative vs. positive	3	233	Fixed	4.367	1.626–11.729	0.003	36.70%	0.206
MUM1	negative vs. positive	3	233	Fixed	3.365	1.578–7.175	0.002	22.80%	0.274
MYC	negative vs. positive	3	244	Fixed	1.252	0.647–2.420	0.504	0	0.627
ki-67%	low vs. high	4	397	Fixed	0.876	0.535–1.433	0.598	0	0.987

IPI international prognostic index; ECOG Eastern Cooperative Oncology Group; GCB germinal center B-cell-like; OR odd ratio; LDH Lactic dehydrogenase; CR complete remission

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