Skip to main content

Advertisement

Table 5 Cox proportional hazard analysis for clinical variables in relationship to metastasis-free survival in AFP ≤ 35 ng/mL subgroup (n = 270)

From: Is there a sex difference in postoperative prognosis of hepatocellular carcinoma?

  HR 95% CI P
Univariate analysis
 Age, per year 1.017 0.992 – 1.042 0.188
 Gender, Male = 1 3.572 1.104 – 11.553 0.034
 Anti-HCV, positive = 1 1.208 0.618 – 2.360 0.581
 HBsAg, positive = 1 0.866 0.456 – 1.643 0.660
 Liver cirrhosis, yes = 1 1.125 0.610 – 2.074 0.707
 Microvascular invasion, yes = 1 2.742 1.491 – 5.041 0.001
 Macrovascular invasion, yes = 1 4.081 1.999 – 8.332 < 0.001
 Histology grade, per grade 1.473 0.951 – 2.281 0.083
 Capsule, yes = 1 0.980 0.511- 1.880 0.952
 Tumor number, per number 1.308 1.007 – 1.700 0.044
 Ascites yes = 1 1.048 0.253 – 4.348 0.948
 Alcoholism yes = 1 1.043 0.535 – 2.033 0.9903
 Largest tumor size, per cm 1.009 0.973 – 1.047 0.613
 AFP, per ng/mL 1.037 1.003 – 1.073 0.035
 Albumin, per g/L 0.740 0.442 – 1.239 0.252
 Bilirubin, per mg/dL 0.954 0.713 – 1.275 0.748
 PT, per sec 1.084 0.903 – 1.302 0.385
 Creatinine, per mg/dL 0.891 0.567 – 1.399 0.615
 AST, per U/L 1.001 0.998 – 1.004 0.534
 ALT, per U/L 1.000 0.996 – 1.003 0.787
Multivariate analysis
 Gender, Male = 1 3.413 1.042 – 11.183 0.043
 Microvascular invasion, yes = 1 2.687 1.426 – 5.060 0.002
 Macrovascular invasion, yes = 1 4.209 1.867 – 9.490 0.001
 Tumor number, per number 1.004 0.749 – 1.347 0.977
 AFP, per ng/mL 1.052 1.015 – 1.089 0.005
  1. AFP alpha-fetoprotein, PT prothrombin time, AST aspartate aminotransferase, ALT alanine aminotransferase, HR hazard ratio, CI confidence interval; Values in bold, P < 0.05