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Table 4 Correlation between Cyclin D1 immunoreactivity and clinico-pathological data

From: Clinical impact of a cytological screening system using cyclin D1 immunostaining and genomic analysis for the diagnosis of thyroid nodules

Paramater Cyclin D1 (Immunolabeling ratio 15.7%) p
Immunolabeling below threshold Immunolabeling above threshold
Tumor size (mm)
 <40 15 14.70% 68 66.70% 0.59
40 3 2.90% 16 15.70%  
Extra-thyroidal extension
 Present 3 2.90% 54 52.90% 0.0002*
 Absent 15 14.70% 30 29.40%  
Intraglandular metastasis
 Present 0 0.00% 26 25.50% 0.0006*
 Absent 18 17.70% 58 56.90%  
Lymph node metastasis
 Positive 1 1.00% 49 48.00% <.0001*
 Negative 17 16.70% 35 34.30%  
Distant metastasis
 Present 4 3.90% 24 23.50% 0.6
 Absent 14 13.70% 60 58.80%  
  1. *: significant