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Table 1 A statistical analysis of serum content and the muscle key proteins of a protein synthesis pathway

From: A leucine-rich diet modulates the mTOR cell signalling pathway in the gastrocnemius muscle under different Walker-256 tumour growth conditions

  7th day 14th day 21st day
Serum Insulin profile n.s. *W < C *W < C
*L > C
*W < WL
Serum Walker Factor n.d. n.d. *W > C
*W > L
*W > WL; P = 0.0517
Phospho IRS-1/total IRS-1 ratio *W < C *W < C; P = 0.056 n.s.
Phospho AKT-PKB n.s. *WL < L *W > C
*W > L
*WL < W
Phospho ERK-MAPK n.s. n.s. *W > C
*W > L
Phospho mTOR n.s. n.s. *WL > C
*WL > L
*WL > W
Phospho p70S6K n.s. n.s. n.s.
pmTOR/p70S6K-1 ratio *L > C
*WL < C
n.s. *W < C
*WL > C,L
*WL > W
Phospho RAG-A *L > C
*WL > C
*WL > L
*L > C
*W > C
*WL > C
*L > C
*WL > C
*W < L
*WL > W
Phospho JNK *W > WL n.s. n.s.
Phospho STAT3 n.s. n.s. *W > C
Phospho STAT6 n.s. *W > C *W > C
*W > L
Phenylalanine Incorporation n.d. n.d. *C > W
*L > WL
*WL > W
Leucine Incorporation n.d. n.d. *W < C; p = 0,058
KIC Incorporation n.d. n.d. *C > W
*WL > W
Tyrosine release n.d. n.d. *W > C
*WL > L
*W > WL
Total protein net n.d. n.d. *C > W
*L > WL
*WL > W
  1. Legend: C, control group; W, Walker tumour-bearing group; L, rats fed a leucine-rich diet; WL, tumour-bearing rats fed a leucine-rich diet. Two Way ANOVA analysis followed by the Fisher’s LSD multiple-comparison test (P < 0.05 values). * The mean difference of 0.05 is statistically significant. n.s. = non-significant. n.d. = non-determined. For details, see the Materials and Methods and Results sections