Skip to main content

Table 1 List Genes containing germline and somatic mutations that were significantly differentially expressed between tumors and controls

From: Integrating germline and somatic variation information using genomic data for the discovery of biomarkers in prostate cancer

Genes

Region

SNP ID

GWAS

P-value

EXP

P-Value

FDR

Germline mutations

Somatic mutations

LRP1B

2q21.2

rs10210358

2.00E-06

5.57E-26

2.30E-24

1

29

PKHD1

6p21.2

rs10498792

3.00E-06

0.004895

0.008362

1

11

TMPRSS2

21q22.3

rs1041449

3.00E-08

7.18E-06

1.92E-05

1

9

DNAH5

5p15.2

rs4463179

2.00E-06

5.10E-18

7.01E-17

1

8

MYO6

6q14.1

rs9443189

4.00E-08

1.83E-08

7.13E-08

1

7

ATF7IP

12p13.1

rs3213764

2.00E-09

9.80E-06

2.56E-05

1

7

TBX3

12q24.21

rs11067228

1.00E-14

0.002485

0.004448

1

7

NKX3–1

8p21.2

rs13272392

4.00E-34

2.12E-22

5.29E-21

4

6

KLK3

19q13.41

rs2739472

9.00E-186

1.12E-17

1.48E-16

15

6

BCL11A

2p16.1

rs2556375

6.00E-19

8.61E-16

8.83E-15

1

6

GLI2

2q14

rs11122834

5.00E-06

2.11E-10

1.06E-09

1

6

ZNF827

4q31.22

rs56935123

4.00E-09

9.84E-05

0.00022

2

6

EHBP1

2p15

rs2430386

9.00E-12

0.016795

0.026074

6

6

HOXB13

8q24.21

rs188140481

6.00E-34

1.57E-28

9.23E-27

2

5

PPFIBP2

11p15.4

rs12791447

4.00E-08

2.55E-11

1.46E-10

1

5

NOTCH4

6p21.3

rs3096702

4.78E-09

1.70E-06

4.96E-06

1

5

IL16

15q26.3

rs7175701

9.8E-08

0.005231

0.008879

1

5

DDHD1

14q22.1

rs8008270

2.00E-14

0.023066

0.03488

1

5

PDLIM5

4q22

rs17021918

4.2E-15

2.67E-23

7.52E-22

2

4

POU5F1B

8q24.21

rs16901979

1.00E-16

4.98E-19

7.86E-18

2

4

EBF2

8p21.2

rs11135910

8.00E-11

9.81E-10

4.50E-09

1

4

TLR4

9q33.1

rs6478343

2.00E-08

7.99E-05

0.000181

1

4

TNS3

7p12.3

rs56232506

9.00E-09

0.009192

0.014986

1

4

FGFR2

10q26.12

rs10886902

2.00E-53

3.68E-25

1.36E-23

2

3

NLGN3

Xq13.1

rs4844289

1.00E-09

1.44E-24

4.91E-23

1

3

MLPH

2q37.2

rs2292884

4.00E-08

1.06E-20

2.11E-19

1

3

FAM111A

11q12.1

rs1938781

1.10E-10

1.75E-19

2.94E-18

1

3

RAD51B

14q23

rs7141529

2.77E-10

3.57E-12

2.28E-11

1

3

ZNF652

17q21.32

rs7210100

3.4E-13

2.05E-11

1.18E-10

1

3

ADAM15

1q21.3

rs1218582

2.00E-08

2.34E-11

1.34E-10

1

3

TBX5

12q24.1

rs1270884

6.75E-11

8.52E-07

2.61E-06

2

3

CNNM2

10q24.32

rs3850699

5.00E-10

0.001153

0.002181

1

3

FERMT2

14q22.1

rs8008270

1.78E-14

1.98E-26

8.69E-25

1

2

SLC25A37

8p21.2

rs4614003

1.00E-15

2.31E-17

2.93E-16

2

2

FOXP4

6p21.1

rs1983891

7.6E-08

2.60E-13

1.93E-12

1

2

NGFR

17q21.32

rs11650494

2.00E-09

6.87E-12

4.23E-11

1

2

FAM111B

11q12.1

rs1938781

1.10E-10

1.08E-11

6.47E-11

1

2

MYC

8q24.21

rs10505477

7.00E-21

7.25E-10

3.39E-09

8

2

NAALADL2

3q26.31

rs78943174

4.00E-08

9.47E-08

3.34E-07

1

2

KCNN3

1q21.3

rs1218582

1.95E-08

9.70E-08

3.42E-07

1

2

MDM4

1q32

rs4245739

2.01E-11

0.003357

0.005885

1

2

SERPINA3

14q32.13

rs8023057

2.00E-15

0.010238

0.016542

1

2

RFX6

6q22.31

rs339331

2.00E-12

0.015259

0.02389

2

2

SHROOM2

Xp22.2

rs2405942

2.37E-10

0.017786

0.027489

1

2

WDR11

10q26.13

rs10749415

9.00E-25

0.032303

0.047546

2

2

JAZF1

7p15.2

rs1080784

2.96E-10

9.20E-30

6.55E-28

7

1

KLK2

19q13.33

rs1354774

6.00E-20

1.78E-23

5.15E-22

5

1

SLC45A3

1q32.1

rs12409639

2.36E-19

1.12E-11

6.71E-11

4

1

SLC22A3

6q25.3

rs4646284

3.2E-52

0.000156

0.000339

4

1

Back to article page

BMC Cancer

ISSN: 1471-2407

Contact us