Table 2 Patient demographics and clinical characteristics
Overall (N = 1030) | Stage IIIB (n = 119) | Stage IV (n = 911) | |
|---|---|---|---|
Mean agea, years (SD) | 64.5 (10.1) | 62.4 (10.6) | 64.8 (10.0) |
Male sex, n (%) | 679 (65.9) | 86 (72.3) | 593 (65.1) |
Mean body mass indexb, kg/m2 (SD) | 24.0 (3.4) | 24.4 (3.7) | 24.0 (3.3) |
Current/former smokerc, n (%) | 787 (77.9) | 98 (83.8) | 689 (77.2) |
Histological tumour type, n (%) | |||
Non-squamous | 724 (70.3) | 73 (61.3) | 651 (71.5) |
Squamous | 306 (29.7) | 46 (38.7) | 260 (28.5) |
Mean disease durationd, weeks (SD) | 35.9 (45.0) | 27.6 (40.1) | 37.1 (45.5) |
Receiving second- or later-line therapye, n (%) | 302 (29.5) | 21 (17.6) | 281 (31.1) |
ECOG PS, n (%) | |||
0 | 200 (19.4) | 24 (20.2) | 176 (19.3) |
1 | 448 (43.5) | 53 (44.5) | 395 (43.4) |
2 | 282 (27.4) | 29 (24.4) | 253 (27.8) |
3 | 82 (8.0) | 13 (10.9) | 69 (7.6) |
4 | 18 (1.7) | 0 (0.0) | 18 (2.0) |
Comorbiditiesf, n (%) | |||
COPD | 362 (35.3) | 36 (30.5) | 326 (35.9) |
Hypertension | 335 (32.7) | 25 (21.2) | 310 (34.1) |
Anxiety | 158 (15.4) | 25 (21.2) | 133 (14.6) |
Hyperlipidaemia | 131 (12.8) | 16 (13.6) | 115 (12.7) |
Depression | 112 (10.9) | 15 (12.7) | 97 (10.7) |
Diabetes mellitus | 112 (10.9) | 15 (12.7) | 97 (10.7) |
Emphysema | 107 (10.4) | 8 (6.8) | 99 (10.9) |
Ischaemic heart disease | 90 (8.8) | 7 (5.9) | 83 (9.1) |
Bronchitis | 87 (8.5) | 8 (6.8) | 79 (8.7) |
Peripheral vascular disease | 67 (6.5) | 4 (3.4) | 63 (6.9) |
None | 314 (30.6) | 35 (29.7) | 279 (30.7) |
Current employment statusg, n (%) | |||
Retired | 614 (60.4) | 66 (55.9) | 548 (61.0) |
Working (full-time) | 149 (14.7) | 28 (23.7) | 121 (13.5) |
Working (part-time) | 65 (6.4) | 4 (3.4) | 61 (6.8) |
Unemployed | 105 (10.3) | 11 (9.3) | 94 (10.5) |
Otherh | 83 (8.2) | 9 (7.6) | 74 (8.2) |