Fig. 6

a Hierarchical cluster analysis of ERH KD and NC cells. Heatmap colors represent the mean-centered fold change expression in log-space. b. According to the results of the ERH microarray, several differentially expressed genes related to cell migration and invasion were selected. A network map of these genes shows that the MYC gene was in the center position. c shows the expression of the MYC gene after ERH knockdown in BUC 5637 and T24 cells using the real-time PCR method. MYC gene expression in the ERH KD group was 0.345 and 0.568 times that of the ERH NC group in 5637 and T24 cells, respectively (all p < 0.01). d shows the Western blot analysis of MYC protein expression in BUC 5637 and T24 cells following ERH knockdown. The expression of MYC protein in the ERH KD group was significantly lower than that in the ERH NC group