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Table 3 Association between micro-lymphatic vessel density (MLVD) and clinicopathological characteristics of the patients with ICC

From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma

Clinicopathological Characteristics MLVD Analysis
Low MLVD High MLVD p value
No. of patients 56 50  
Age (years)
  < 60 35 (62.5%) 21 (42.0%) 0.035*
  ≥ 60 21 (37.5%) 29 (58.0%)  
Gender
 Male 30 (53.6%) 32 (64.0%) 0.277
 Female 26 (46.4%) 18 (36.0%)  
HBV infection
 Absent 27 (48.2%) 37 (74.0%) 0.007*
 Present 29 (51.8%) 13 (26.0%)  
Preoperative AFP (μg/l)
  < 9 40 (71.4%) 38 (76.0%) 0.594
  ≥ 9 16 (28.6%) 12 (24.0%)  
Preoperative CA19–9 (U/ml)
  < 35 19 (33.9%) 14 (28.0%) 0.511
  ≥ 35 37 (66.1%) 36 (72.0%)  
Tumor size (mm)
  < 50 27 (48.2%) 18 (36.0%) 0.204
  ≥ 50 29 (51.8%) 32 (64.0%)  
Tumor number
 Single 50 (89.3%) 39 (78.0%) 0.114
 Multiple 6 (10.7%) 11 (22.0%)  
Vascular invasion
 Absent 41 (73.2%) 37 (74.0%) 0.921
 Present 15 (26.8%) 13 (26.0%)  
Lymph node metastasis
 Absent 40 (71.4%) 18 (36.0%) < 0.001*
 Present 16 (28.6%) 32 (64.0%)  
Histologic differentiation
 Well or moderate 29 (51.8%) 23 (46.0%) 0.552
 Poor 27 (48.2%) 27 (54.0%)  
Distribution
 Unilobar 24 (42.9%) 17 (34.0%) 0.350
 Bilobar 32 (57.1%) 33 (66.0%)  
Perineural sheath infiltration
 Absent 49 (87.5%) 43 (86.0%) 0.820
 Present 7 (12.5%) 7 (14.0%)  
Tumor recurrence
 Absent 33 (58.9%) 1 (2.0%) < 0.001*
 Present 23 (41.1%) 49 (98.0%)  
TNM stage
 I/II 38(67.9%) 10(20.0%) < 0.001*
 III/IV 18(32.1%) 40(80.0%)  
  1. *p< 0.05 defined as statistical significance