Table 3 Association between micro-lymphatic vessel density (MLVD) and clinicopathological characteristics of the patients with ICC
From: Tumor-associated lymphangiogenesis predicts unfavorable prognosis of intrahepatic cholangiocarcinoma
Clinicopathological Characteristics | MLVD Analysis | ||
|---|---|---|---|
Low MLVD | High MLVD | p value | |
No. of patients | 56 | 50 | Â |
Age (years) | |||
  < 60 | 35 (62.5%) | 21 (42.0%) | 0.035* |
  ≥ 60 | 21 (37.5%) | 29 (58.0%) |  |
Gender | |||
 Male | 30 (53.6%) | 32 (64.0%) | 0.277 |
 Female | 26 (46.4%) | 18 (36.0%) |  |
HBV infection | |||
 Absent | 27 (48.2%) | 37 (74.0%) | 0.007* |
 Present | 29 (51.8%) | 13 (26.0%) |  |
Preoperative AFP (μg/l) | |||
  < 9 | 40 (71.4%) | 38 (76.0%) | 0.594 |
  ≥ 9 | 16 (28.6%) | 12 (24.0%) |  |
Preoperative CA19–9 (U/ml) | |||
  < 35 | 19 (33.9%) | 14 (28.0%) | 0.511 |
  ≥ 35 | 37 (66.1%) | 36 (72.0%) |  |
Tumor size (mm) | |||
  < 50 | 27 (48.2%) | 18 (36.0%) | 0.204 |
  ≥ 50 | 29 (51.8%) | 32 (64.0%) |  |
Tumor number | |||
 Single | 50 (89.3%) | 39 (78.0%) | 0.114 |
 Multiple | 6 (10.7%) | 11 (22.0%) |  |
Vascular invasion | |||
 Absent | 41 (73.2%) | 37 (74.0%) | 0.921 |
 Present | 15 (26.8%) | 13 (26.0%) |  |
Lymph node metastasis | |||
 Absent | 40 (71.4%) | 18 (36.0%) | < 0.001* |
 Present | 16 (28.6%) | 32 (64.0%) |  |
Histologic differentiation | |||
 Well or moderate | 29 (51.8%) | 23 (46.0%) | 0.552 |
 Poor | 27 (48.2%) | 27 (54.0%) |  |
Distribution | |||
 Unilobar | 24 (42.9%) | 17 (34.0%) | 0.350 |
 Bilobar | 32 (57.1%) | 33 (66.0%) |  |
Perineural sheath infiltration | |||
 Absent | 49 (87.5%) | 43 (86.0%) | 0.820 |
 Present | 7 (12.5%) | 7 (14.0%) |  |
Tumor recurrence | |||
 Absent | 33 (58.9%) | 1 (2.0%) | < 0.001* |
 Present | 23 (41.1%) | 49 (98.0%) |  |
TNM stage | |||
 I/II | 38(67.9%) | 10(20.0%) | < 0.001* |
 III/IV | 18(32.1%) | 40(80.0%) |  |