DL (Dose Level) | Olaparib (orally) | STUPP protocol | |
---|---|---|---|
Temozolomide | IMRT | ||
Each treatment will start on a Monday | |||
DL0 | 50 mg Q12H, Monday to Tuesday | • 75 mg/m2/day until end of IMRT • 4 weeks after the end of IMRT: 6 cycles of temozolomide at the dose of 150 mg/m2/day on days 1 to 5 every 28 days | • IMRT will begin at day 1 • Prescription doses will be 60Gy/30fr/6 weeks • The PTV receives 95 to 107% of the prescribed dose |
DL1 (starting dose level) | 50 mg Q12H, Monday to Wednesday | ||
DL2 | 100 mg Q12H, Monday to Wednesday | ||
DL3 | 100 mg Q12H, Monday to Friday | ||
DL4 | 200 mg Q12H, Monday to Wednesday | ||
DL5 | 200 mg Q12H, Monday to Friday | ||
DL6 | 200 mg Q12H, continuously |