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Table 3 (A) Cox Proportional Hazard ratios, 95% Confidence intervals (95%CI) and p-values for survival analysis of relapse free survival dichotomised based on presence or absence and of NUP98 IHC expression in the in-house TNBC TMA1 with matched gene expression. (B) Cox Proportional Hazard ratios, 95% Confidence intervals (95%CI) and p-values for univariate and multivariate survival analysis of relapse free and overall survival stratified based on absent (0), low (1) or high (2) NUP98 IHC expression in the in-house TNBC TMA1 with matched gene expression. Cox Proportional Hazard ratios, 95% Confidence intervals (95%CI) and p-values for univariate and multivariate survival analysis of (C) relapse free and (D) overall survival stratified based on absent (0), low (1) or high (2) NUP98 IHC expression in the in-house TNBC TMA2. (E) Cox Proportional Hazard ratios, 95% Confidence intervals (95%CI) and p-values for survival analysis of relapse free survival dichotomised based on presence or absence and of NUP96 IHC expression in the in-house TNBC TMA2

From: NUP98 – a novel predictor of response to anthracycline-based chemotherapy in triple negative breast cancer

A
TNBC TMA #1 N(n) HR %95 CI p-value
Relapse Free Survival 53(16) Univariate
Nup98 absent 15 (1) 1   
present 37 (14) 6.707 0.8815–51.04 0.066
B
TNBC TMA #1 N(n) HR %95 CI p-value
Relapse Free Survival 53(16) Univariate
Nup98 low 15 (1) 1   
medium 19 (5) 4.24 0.495–36.33 0.1871
high 18 (9) 10.373 1.3035–82.54 0.0271*
Relapse Free Survival Multivariate
Nup98 low 15 (1) 1   
medium 19 (5) 3.7522 0.41815–33.670 0.2375
high 18 (9) 13.32 1.39448–127.242 0.0245*
Overall Survival 53 (12) Univariate
Nup98 low 15 (1) 1   
medium 19 (3) 2.5638 0.266–24.65 0.415
high 18 (6) 5.8375 0.7016–47.57 0.103
C
TNBC TMA #2 N(n) HR %95 CI p-value
Relapse Free Survival 63(24) Univariate
Nup98 low 10 (1) 1   
medium 34 (14) 5.044 0.6629–38.38 0.1181
high 19 (9) 7.293 0.9324–57.04 0.0583
  Multivariate
Nup98 low 10 (1) 1   
medium 34 (14) 4.39 0.051–37.87 0.1783
high 19 (9) 8.95 1.06–75.11 0.0433*
D
TNBC TMA #2 N(n) HR %95 CI p-value
Relapse Free Survival 63(24) Univariate
Nup98 low 10 (1) 1   
medium 34 (14) 5.086 0.6685–38.70 0.1162
high 19 (9) 6.558 0.8293–51.86 0.0747
  Multivariate
Nup98 low 10 (1) 1   
medium 34 (14) 4.71 0.552–40.11 0.1566
high 19 (9) 7.91 0.94–66.62 0.0570
E
TNBC TMA #2 N(n)
53(16)
HR %95 CI p-value
Relapse Free Survival  
Nup96 absent 53(21) 1   
present 11(5) 1.378 0.4839–4.234 0.5173
Overall Survival  
Nup96 absent 53 (20) 1   
present 11 (5) 1.418 0.4943–4.445 0.04825*