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Table 2 Genetic model analyses of IL1A SNPs and the risk of CRC

From: IL1A polymorphisms is a risk factor for colorectal cancer in Chinese Han population: a case control study

SNP_ID

Genotypes

Controls, n (%)

Patients, n (%)

Without adjustment

With adjustment

OR (95% CI)

p a

OR (95% CI)

p b

rs3783550

 

G/G

206 (44.5%)

103 (41.7%)

1.00

 

1.00

 

Codominant

G/T

212 (45.8%)

111 (44.9%)

1.05 (0.75–1.46)

0.330

1.01 (0.72–1.44)

0.310

T/T

45 (9.7%)

33 (13.4%)

1.47 (0.88–2.44)

 

1.49 (0.88–2.52)

 

Dominant (ref: G/G)

G/T-T/T

257 (55.5%)

144 (58.3%)

1.12 (0.82–1.53)

0.470

1.10 (0.79–1.52)

0.580

Recessive (ref: G/G + G/T)

T/T

45 (9.7%)

33 (13.4%)

1.43 (0.89–2.31)

0.140

1.48 (0.90–2.43)

0.130

rs3783546

 

G/G

206 (44.7%)

104 (41.9%)

1.00

 

1.00

 

Codominant

G/C

210 (45.5%)

113 (45.6%)

1.07 (0.77–1.48)

0.500

1.02 (0.73–1.45)

0.500

C/C

45 (9.8%)

31 (12.5%)

1.36 (0.82–2.28)

 

1.37 (0.80–2.34)

 

Dominant (ref: G/G)

G/C-C/C

255 (55.3%)

144 (58.1%)

1.12 (0.82–1.53)

0.480

1.09 (0.78–1.51)

0.620

Recessive (ref: G/G + G/C)

C/C

45 (9.8%)

31 (12.5%)

1.32 (0.81–2.15)

0.270

1.35 (0.82–2.24)

0.240

rs2856838

 

G/G

257 (55.8%)

143 (57.7%)

1.00

 

1.00

 

Codominant

G/A

180 (39%)

83 (33.5%)

0.83 (0.60–1.15)

0.096

0.83 (0.58–1.17)

0.063

A/A

24 (5.2%)

22 (8.9%)

1.65 (0.89–3.04)

 

1.84 (0.96–3.50)

 

Dominant (ref:G/G)

G/A-A/A

204 (44.2%)

105 (42.3%)

0.93 (0.68–1.26)

0.620

0.94 (0.68–1.31)

0.720

Recessive (ref: G/G + G/A)

A/A

24 (5.2%)

22 (8.9%)

1.77 (0.97–3.23)

0.064

1.98 (1.05–3.72)

0.036

rs1609682

 

G/G

205 (44.4%)

105 (42.5%)

1.00

 

1.00

 

Codominant

G/T

212 (45.9%)

109 (44.1%)

1.00 (0.72–1.40)

0.350

0.97 (0.68–1.37)

0.310

T/T

45 (9.7%)

33 (13.4%)

1.43 (0.86–2.38)

 

1.45 (0.85–2.45)

 

Dominant (ref: G/G)

G/T-T/T

257 (55.6%)

142 (57.5%)

1.08 (0.79–1.47)

0.630

1.05 (0.76–1.46)

0.770

Recessive (ref: G/G + G/T)

T/T

45 (9.7%)

33 (13.4%)

1.43 (0.89–2.31)

0.150

1.47 (0.89–2.42)

0.130

rs3783521

 

A/A

206 (44.5%)

103 (41.7%)

1.00

 

1.00

 

Codominant

G/A

212 (45.8%)

112 (45.3%)

1.06 (0.76–1.47)

0.400

1.02 (0.72–1.44)

0.410

G/G

45 (9.7%)

32 (13.0%)

1.42 (0.85–2.37)

 

1.42 (0.84–2.42)

 

Dominant (ref: A/A)

G/A-G/G

257 (55.5%)

144 (58.3%)

1.12 (0.82–1.53)

0.470

1.09 (0.79–1.51)

0.610

Recessive (ref: A/A + G/A)

G/G

45 (9.7%)

32 (13.0%)

1.38 (0.85–2.24)

0.190

1.41 (0.86–2.33)

0.180

  1. SNP Single nucleotide polymorphism, OR Odds ratio; 95% CI: 95% confidence interval
  2. pa-values were calculated by logistic regression analysis with the comparison between CRC patients and healthy controls
  3. pb-values were calculated by logistic regression analysis with adjustments for age and gender
  4. Bold italics indicates the SNP with statistical significance (p < 0.05)
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BMC Cancer

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