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Fig. 4 | BMC Cancer

Fig. 4

From: Circulating tumor cell investigation in breast cancer patient-derived xenograft models by automated immunofluorescence staining, image acquisition, and single cell retrieval and analysis

Fig. 4

Preclinical chemotherapy treatment scheme and findings in PDX-bearing mice of BCM-4272 and BCM-3887. a Overall experimental scheme. Mice in two PDX models (BCM-4272 and BCM-3887) were randomized to receive either vehicle, docetaxel 20–30 mg/kg; carboplatin 50 mg/kg; or their combination. Intraperitoneal treatment was given every week for 4 weeks. Tumor volume and CTCs were evaluated at the end of 4-week treatment (N = 2–5 in each treatment group) in mice with residual disease for each PDX model. b and c Tumor volume and CTC numbers in mice treated with vehicle or various chemotherapy regimens for BCM-4272 and BCM-3887 models, respectively. Treatment with various chemotherapy regimens reduced tumor growth in both triple-negative BC-PDX models, BCM-4272 and BCM-3887 however CTCs persisted despite tumor reduction in some regimens

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BMC Cancer

ISSN: 1471-2407

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